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NesT-NABind: a Nested Transformer for Nucleic Acid-Binding Site Prediction on Protein Surface.
J Chem Inf Model
January 2025
School of Information Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Pudong New Area, Shanghai 201210, China.
Protein-nucleic acid interactions play a crucial role in many physiological processes. Identifying the binding sites of nucleotides on the protein surface is the prerequisite for understanding the molecular recognition mechanisms between the two types of macromolecules and also provides the information to design or generate molecule modulators against these sites to manipulate biological function according to specific requirements. Existing studies mainly focus on characterizing local surfaces around sites, often neglecting the interrelationships among these sites and the global protein information.
View Article and Find Full Text PDFAssociations of sleep disorders and autonomic dysfunction with cardio-renal function.
Sleep Breath
November 2024
Department of Diabetes, Endocrinology and Clinical Immunology, School of Medicine, Hyogo Medical University, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Purpose: Studies have found that sleep disorders and autonomic dysfunction are associated with several metabolic diseases. Moreover, these factors also been reported to be related with the development of atherosclerosis and cardiovascular disease independent of other known factors, and details related to their pathogenesis have recently received increased attention. Additionally, the rates of incidence of heart and renal failure are showing an increasing trend.
View Article and Find Full Text PDFExtracellular vesicles (EVs) composed of various biologically active constituents, such as proteins, nucleic acids, lipids, and metabolites, have emerged as a noteworthy mode of intercellular communication. There are several categories of EVs, including exosomes, microvesicles, and apoptotic bodies, which largely differ in their mechanisms of formation and secretion. The amount of evidence indicated that changes in the EV quantity and composition play a role in multiple aspects of cancer development, such as the transfer of oncogenic signals, angiogenesis, metabolism remodeling, and immunosuppressive effects.
View Article and Find Full Text PDF[INTEGRATING SEX AND GENDER DIFFERENCES/GENDER MEDICINE INTO THE FACULTY OF MEDICINE CURRICULUM].
Harefuah
July 2024
Linda Joy Pollin Cardiovascular Wellness Center for Women, Hadassah University Medical Center, Jerusalem, Israel.
In recent decades, the recognition of the importance of sex, gender and their interrelationship for health research and for the practice of medicine has grown. Accordingly, the move to include gender medicine in medical school curricula has gained momentum in many countries. This article reviews the challenges of integrating this subject into medical school curricula and details the recent initiative to mainstream gender medicine into the six-year curriculum of the Hadassah-Hebrew University Medical School in Jerusalem, Israel.
View Article and Find Full Text PDFTaste receptor T1R3 regulates testosterone synthesis via the cAMP-PKA-SP1 pathway in testicular Leydig cells.
Theriogenology
January 2025
Key Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, 550025, China; Key Laboratory of Animal Genetics, Breeding and Reproduction, Guiyang, 550025, China; College of Animal Science, Guizhou University, Guiyang, 550025, China. Electronic address:
Taste receptor type 1 subunit 3 (T1R3) is a G protein-coupled receptor encoded by the TAS1R3 gene that can be specifically activated by certain sweeteners or umami agents for sweet/umami recognition. T1R3 is a potential target for regulating male reproduction. However, studies on the impact of non-nutritive sweeteners on reproduction are limited.
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