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Background: Existing therapeutic approaches in Alzheimer's disease (AD) targeting beta-amyloid and tau proteins have shown limited success. Shigellosis, an intestinal infection caused by Shigella, is capable of colonizing the human intestinal epithelium and has been associated with focal adhesions. Rap1 signaling is associated with cancer and cell adhesions.
View Article and Find Full Text PDFThe efficient separation of bioactive components from Eucommia ulmoides Oliver using membrane filtration technology and its mechanisms in preventing alcoholic liver disease.
Carbohydr Polym
March 2025
College of Mechanical and Electronic Engineering, Northwest A&F University, Yangling 712100, China; College of Forestry, Northwest A&F University, Yangling 712100, China; Western Scientific Observation and Experiment Station for Development and Utilization of Rural Renewable Energy, M.O.A, Northwest Agriculture & Forestry University, Yangling 712100, China. Electronic address:
The efficient extraction and purification of active components from Eucommia ulmoides Oliver (EUO) are crucial for their utilization. The structure and properties of the prepared EUO leaf polysaccharides (ELPs) and extractum (ELE) were comprehensively characterized in this study, and the intervention mechanism of the EUO polysaccharides and extractum in alcoholic liver disease (ALD) were investigated. The yield of EUO extractum was 24.
View Article and Find Full Text PDFMetagenomic characterization of oral microbiome signatures to predict upper gastrointestinal and pancreaticobiliary cancers: a case-control study.
J Transl Med
January 2025
Department of Laboratory Medicine, Seoul National University College of Medicine, 103, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
Background: This study investigated the oral microbiome signatures associated with upper gastrointestinal (GI) and pancreaticobiliary cancers.
Methods: Saliva samples from cancer patients and age- and sex-matched healthy controls were analyzed using 16S rRNA-targeted sequencing, followed by comprehensive bioinformatics analysis.
Results: Significant dissimilarities in microbial composition were observed between cancer patients and controls across esophageal cancer (EC), gastric cancer (GC), biliary tract cancer (BC), and pancreatic cancer (PC) groups (R = 0.
Characterization of the hepatic flora and metabolome in nonalcoholic fatty liver disease.
Front Microbiol
December 2024
Department of Gastroenterology, Yan'an Hospital Affiliated to Kunming Medical University, Kunming, China.
Background/aim: The purpose of this study was to examine the hepatic bacterial composition and metabolome characteristics of patients with NAFLD using 16S rDNA sequencing and metabolomics. The results of the study revealed substantial differences in hepatic bacterial composition and metabolites between the NAFLD group and the control group. These differences were used to identify potential biomarkers that could be employed to diagnose NAFLD.
View Article and Find Full Text PDFDecomposition of the pangenome matrix reveals a structure in gene distribution in the species.
mSphere
December 2024
Department of Bioengineering, University of California, San Diego, La Jolla, California, USA.
Unlabelled: Thousands of complete genome sequences for strains of a species that are now available enable the advancement of pangenome analytics to a new level of sophistication. We collected 2,377 publicly available complete genomes of for detailed pangenome analysis. The core genome and accessory genomes consisted of 2,398 and 5,182 genes, respectively.
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