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The loss of the PDIM/PGL virulence lipids causes differential secretion of ESX-1 substrates in .
mSphere
May 2024
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
The mycobacterial cell envelope is a major virulence determinant in pathogenic mycobacteria. Specific outer lipids play roles in pathogenesis, modulating the immune system and promoting the secretion of virulence factors. ESX-1 (ESAT-6 system-1) is a conserved protein secretion system required for mycobacterial pathogenesis.
View Article and Find Full Text PDFMeat juice as a feasible alternative sample for tuberculosis surveillance in large game.
Vet Ital
March 2024
CECAV - Animal and Veterinary Research Centre, Trás-os-Montes e Alto Douro University, Vila Real, Portugal.
In hunted animals, quality of blood samples may often be compromised. Alternative samples, such as meat juice, may offer an advantage to perform serological tests. This study evaluates if meat juice is a feasible alternative sample to perform the Tuberculosis ELISA test in hunted large game.
View Article and Find Full Text PDFAbsence of Tuberculosis-Causing from Slaughtered Livestock Tissues and Environmental Samples, Gauteng Province, South Africa.
Int J Microbiol
March 2024
Bacteriology Section, Diagnostic Services Programme, Agricultural Research Council-Onderstepoort Veterinary Institute, Private Bag X05, Onderstepoort 0110, Pretoria, South Africa.
complex (MTBC) is a group of bacteria responsible for causing tuberculosis in animals and humans. In South Africa (S.A), slaughterhouses are registered by the government and closely inspected and audited for hygienic slaughter practices.
View Article and Find Full Text PDFRNGU-NET: a novel efficient approach in Segmenting Tuberculosis using chest X-Ray images.
PeerJ Comput Sci
February 2024
Computer Engineering/Faculty of Engineering and Architecture, Kirikkale University, Kirikkale, Turkey.
Tuberculosis affects various tissues, including the lungs, kidneys, and brain. According to the medical report published by the World Health Organization (WHO) in 2020, approximately ten million people have been infected with tuberculosis. U-NET, a preferred method for detecting tuberculosis-like cases, is a convolutional neural network developed for segmentation in biomedical image processing.
View Article and Find Full Text PDFAssessment of the diagnostic performance of intradermal tuberculin test and post-mortem inspection for the diagnosis of bovine tuberculosis according to WOAH guidelines.
Res Vet Sci
March 2024
Department of Animal Health, UIC Zoonosis y Enfermedades Emergentes ENZOEM, University of Córdoba, International Excellence Agrifood Campus 'CeiA3', University of Córdoba, 14014 Córdoba, Spain.
Bovine tuberculosis (bTB) constitutes a global challenge for public and animal health with still some deficiencies regarding its diagnosis. This study aimed to estimate the accuracy of the single intradermal tuberculin test (SIT) and post-mortem inspection for different diagnostic objectives following WOAH guidelines. Tissue samples from 59 microbiological culture/PCR-positive and 58 microbiological culture/PCR-negative cattle were evaluated.
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