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Parosmia: Pathophysiology and Management.
Curr Allergy Asthma Rep
January 2025
Smell and Taste Clinic, Department of Otorhinolaryngology, Technical University of Dresden, Dresden, Germany.
Purpose Of Review: Parosmia is a qualitative olfactory disorder in which there is a mismatch between the memory of an odor and the actual experience triggered by an odor. There has been a surge in parosmia-related publications since the COVID-19 pandemic. This review summarizes the latest clinical findings, theories on pathophysiology and potential treatment options.
View Article and Find Full Text PDFCorrelation between IL-17 and inflammatory bowel disease.
Egypt J Immunol
January 2025
Department of Biology, Faculty of Science, University of Kufa, Najaf, Iraq.
Inflammatory bowel disease (IBD) is a protracted, persistent gastrointestinal disease that is distinguished by recurring, persistent inflammation of the digestive tract. IBD, including Crohn's disease and ulcerative colitis, is characterized by persistent inflammation due to immune dysregulation. Interleukin -17 (IL-17) contributes significantly to the pathophysiology of IBD, as highlighted in the context of the provided research.
View Article and Find Full Text PDFEndoureteral ablation: A novel technique to occlude the ureter in patients with urinary tract fistulae.
World J Radiol
December 2024
Department of Radiology, Interventional Radiology, Detroit Medical Center/Wayne State University, Detroit, MI 48201, United States.
Urinary fistulae are abnormal connections between the urinary system and adjacent body parts, often resulting from factors such as infection, radiation, malignancy, protracted labor, gynecologic surgery, and gastrointestinal tract surgery. These fistulae can lead to persistent urinary incontinence, skin breakdown, social humiliation, psychosocial trauma, and severe infections. Current treatments include surgical repair, urinary diversion, and ureteral embolization, though these can have complications and are not always successful or feasible for all patients.
View Article and Find Full Text PDFSingle-cell RNA-seq identifies protracted mouse germline X chromosome reactivation dynamics directed by a PRC2-dependent mechanism.
Dev Cell
January 2025
King's College London, Centre for Gene Therapy and Regenerative Medicine, School of Basic & Medical Biosciences, Faculty of Life Sciences and Medicine, London, UK; King's College London, Guy's Hospital Assisted Conception Unit, Department of Women and Children's Health, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, London, UK. Electronic address:
Female primordial germ cells (PGCs) undergo X chromosome reactivation (XCR) during genome-wide reprogramming. XCR kinetics and dynamics are poorly understood at a molecular level. Here, we apply single-cell RNA sequencing and chromatin profiling on germ cells from F mouse embryos, performing a precise appraisal of XCR spanning from migratory-stage PGCs to gonadal germ cells.
View Article and Find Full Text PDFA Narrative Review of Fungal Periprosthetic Joint Infections of the Hip and Knee: Risk Factors, Microbiological Profiles, and Treatment Challenges.
J Clin Med
January 2025
Department of Internal Medicine, 4th Military Clinical Hospital, 50-981 Wroclaw, Poland.
Fungal periprosthetic joint infections (PJIs) are rare but increasingly recognized complications following total joint arthroplasty (TJA). While remains the most common pathogen, non-albicans species and other fungi, such as , have gained prominence. These infections often present with subtle clinical features and affect patients with significant comorbidities or immunosuppression.
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