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Defense mechanisms of against antibiotics: a review.
Front Antibiot
September 2024
Department of Agriculture, Food, and Resource Sciences, University of Maryland Eastern Shore, Princess Anne, MD, United States.
is a foodborne pathogenic bacterium that causes salmonellosis worldwide. Also, is considered a serious problem for food safety and public health. Several antimicrobial classes including aminoglycosides, tetracyclines, phenols, and β-Lactams are used to treat infections.
View Article and Find Full Text PDFResponse Surface D-Optimal Design for Optimizing Fortimicins Production by Micromonospora olivasterospora and New Synergistic Fortimicin-A-Antibiotic Combinations.
Curr Microbiol
January 2025
Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Fortimicins (FTMs) are fortamine-containing aminoglycoside antibiotics (AGAs) produced by M. olivasterospora DSM 43868 with excellent bactericidal activities against a wide range of Enterobacteriaceae and synergistic activity against multidrug-resistant (MDR) pathogens. Fortimicin-A (FTM-A), the most active member of FTMs, has the lowest susceptibility to inactivation by the aminoglycoside modifying enzymes (AMEs).
View Article and Find Full Text PDFIdentification and characterization of a novel chromosome-encoded aminoglycoside -nucleotidyltransferase gene, in sp. TYF-12 isolated from the marine fish intestine.
Front Microbiol
December 2024
Department of Laboratory Sciences, The People's Hospital of Yuhuan, Yuhuan, China.
Background: The mechanisms underlying the resistance of the genus to aminoglycosides are complex, which poses a challenge for the efficient treatment of infectious diseases caused by these pathogens. To help clinicians treat infections more effectively, a more comprehensive understanding of antibiotic resistance mechanisms is urgently needed.
Methods: Plates were streaked to isolate bacteria from the intestinal contents of fish.
Chlorine and UV combination sequence: Effects on antibiotic resistance control and health risks of ARGs.
J Environ Manage
January 2025
Tianjin Key Laboratory of Clean Energy and Pollution Control, School of Energy and Environmental Engineering, Hebei University of Technology, Tianjin, 300401, China. Electronic address:
The effective control of antibiotic resistance in aquatic environments is urgent. The combined chlorine and UV processes (Cl-UV, UV/Cl, and UV-Cl) are considered potential control processes for controlling antibiotic resistance. This study compared the effectiveness of these three processes in real water bodies and the potential health risks associated with antibiotic resistance genes (ARGs) after treatments.
View Article and Find Full Text PDFMining Translation Inhibitors by a Unique Peptidyl-Aminonucleoside Synthetase Reveals Cystocin Biosynthesis and Self-Resistance.
Int J Mol Sci
November 2024
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Puromycin (Puro) is a natural aminonucleoside antibiotic that inhibits protein synthesis by its incorporation into elongating peptide chains. The unique mechanism of Puro finds diverse applications in molecular biology, including the selection of genetically engineered cell lines, in situ protein synthesis monitoring, and studying ribosome functions. However, the key step of Puro biosynthesis remains enigmatic.
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