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Dynamics-aware deep predictive adaptive scanning optical coherence tomography.
Biomed Opt Express
January 2025
Department of Robotics, University of Michigan, USA.
Conventional scanned optical coherence tomography (OCT) suffers from the frame rate/resolution tradeoff, whereby increasing image resolution leads to decreases in the maximum achievable frame rate. To overcome this limitation, we propose two variants of machine learning (ML)-based adaptive scanning approaches: one using a ConvLSTM-based sequential prediction model and another leveraging a temporal attention unit (TAU)-based parallel prediction model for scene dynamics prediction. These models are integrated with a kinodynamic path planner based on the clustered traveling salesperson problem to create two versions of ML-based adaptive scanning pipelines.
View Article and Find Full Text PDFArising amitraz and pyrethroids resistance mutations in the ectoparasitic Varroa destructor mite in Canada.
Sci Rep
January 2025
Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada.
The ectoparasitic mite Varroa destructor remains a great threat for the beekeeping industry, for example contributing to excessive winter colony loss in Canada. For decades, beekeepers have sequentially used the registered synthetic varroacides tau-fluvalinate, coumaphos, amitraz, and flumethrin, leading to the risk of resistance evolution in the mites. In addition to the widespread resistance to coumaphos and pyrethroids, a decline in amitraz efficacy has recently been reported in numerous beekeeping regions in Canada.
View Article and Find Full Text PDFMolecular and biochemical evolution of casbene-type diterpene and sesquiterpene biosynthesis in rice.
J Integr Plant Biol
January 2025
National Key Laboratory for Tropical Crop Breeding, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University, Sanya, 572025, China.
Casbene and neocembrene are casbene-type macrocyclic diterpenes; their derivatives play significant roles in plant defense and have pharmaceutical applications. We had previously characterized a casbene synthase, TERPENE SYNTHASE 28 (OsTPS28), in rice (Oryza sativa). However, the mechanism of neocembrene biosynthesis in rice remained unclear.
View Article and Find Full Text PDFHeterotypic Seeding Generates Mixed Amyloid Polymorphs.
Small Sci
September 2024
Department of Chemistry and Biochemistry, The University of Alabama, 1007E Shelby Hall, Tuscaloosa, AL 35487, USA.
Aggregation of the amyloid β (Aβ) peptide into fibrils represents one of the major biochemical pathways underlying the development of Alzheimer's disease (AD). Extensive studies have been carried out to understand the role of fibrillar seeds on the overall kinetics of amyloid aggregation. However, the precise effect of seeds that are structurally or sequentially different from Aβ on the structure of the resulting amyloid aggregates is yet to be fully understood.
View Article and Find Full Text PDFAnalysis of early efficacy and immune reconstitution after autologous hematopoietic stem cell transplantation in multiple myeloma.
Sci Rep
January 2025
Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, 29 Xinquan Rd, Fuzhou, 350001, China.
This retrospective study aimed to stress the advantages of autologous hematopoietic stem cell transplantation (auto-HSCT) in treating primary MM. Ninety-four MM patients who underwent initial parallel sequential auto-HSCT were selected. Data on efficacy (efficacy evaluation, renal function and hemoglobin recovery), immune reconstitution (B-cell subsets, immunoglobulin levels, T-cell subsets, NK cells, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR)) and hematopoietic reconstitution times were collected and analyzed.
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