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Survival Analysis of Liver Transplants in Patients with Acute Liver Failure from Acetaminophen and Mushroom Toxicity.
Ann Transplant
January 2025
Department of General Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
BACKGROUND Acute liver failure (ALF) remains a critical concern, accounting for about 8% of all liver transplants, with acetaminophen overdose contributing to nearly half of these cases. Besides synthetic toxins, natural toxins such as phallotoxin from Amanita phalloides mushrooms also lead to severe hepatocyte damage. This study investigates the outcomes of liver transplantation (LT) as a life-saving intervention in patients suffering from ALF due to acetaminophen and Amanita phalloides poisoning.
View Article and Find Full Text PDFDesigning iron oxide & silver nanocomposites with phyto- and fungo chemicals for biomedicine: lessons learned.
J Mater Chem B
January 2025
NanoBioMedical Centre, Adam Mickiewicz University in Poznań, 61614 Poznań, Poland.
Article Synopsis
- Multifunctional nanoparticles derived from plants and mushrooms show potential for improved therapy and diagnostics in biomedicine.
- The combination of silver and natural phytochemicals has been found to enhance antimicrobial and anticancer effects, particularly in conjunction with photodynamic therapy.
- Gel formulations of these nanoparticles demonstrate greater effectiveness against cancer cells and adapt to tissue structures, indicating promising applications for targeted cancer treatment and tissue regeneration after surgeries.
Increasing incidence of mycotoxicosis in South-Eastern Germany: a comprehensive analysis of mushroom poisonings at a University Medical Center.
BMC Gastroenterol
December 2024
Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious Diseases, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Background: Mushrooms, an integral component of human diets, range from esteemed delicacies to potentially lethal toxins. The risk of severe poisoning from misidentified species, poses a significant challenge. For clinicians, recognizing mushroom poisoning amidst nonspecific symptoms and determining the specific mushroom ingested are critical yet complex tasks.
View Article and Find Full Text PDF-Associated Liver Failure: Molecular Mechanisms and Management.
Int J Mol Sci
December 2024
Department of Gastroenterology and Hepatology Campbelltown Hospital, Campbelltown, NSW 2560, Australia.
is well-established as one of the most poisonous mushrooms; toxicity from ingestion was reported as early as the first century. Although native to Europe, this ectomycorrhizal fungus has been widely spread and is responsible for liver toxicity in many parts of the world. Toxicity is characterized by delayed gastrointestinal symptoms mimicking acute gastroenteritis followed by severe hepatotoxicity and liver failure with consequent multi-organ failure.
View Article and Find Full Text PDFComa and confirmed epileptiform activity induced by Amanita pantherina poisoning.
Toxicon
January 2025
Bergamo Poison Center, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Amanita pantherina poisoning is a rare event poorly described. The clinical picture is usually associated with the one of A. muscaria, but A.
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