Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jm00269a012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
OST Catalytic Subunit Redundancy Enables Therapeutic Targeting of N-Glycosylation.
bioRxiv
December 2024
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, 06510 USA.
Protein asparagine (N)-glycosylation, which promotes folding and trafficking of cell surface receptors such as the EGFR, has not been considered a viable target in oncology due to the essential and non-redundant enzymatic activities required for glycan synthesis and transfer. In mammals an exception to this rule is the presence of the oligosaccharyltransferase (OST) catalytic subunit paralogs, STT3A and STT3B. Here we delineate the chemical biology of OST inhibitors and develop an approach for limited inhibition of N-glycosylation optimized for downstream effects on EGFR.
View Article and Find Full Text PDFEffect of N-glycosylation on secretion, degradation and lipoprotein distribution of human serum amyloid A4.
Biochim Biophys Acta Mol Cell Biol Lipids
December 2024
Laboratory of Functional Molecular Chemistry, Kobe Pharmaceutical University, Kobe 658-8558, Japan. Electronic address:
Serum amyloid A (SAA) is a family of apolipoproteins predominantly synthesized and secreted by the liver. Human SAA4 is constitutively expressed and contains an N-glycosylation site that is not present in other SAA subtypes. SAA4 proteins are not fully glycosylated, resulting in the presence of both glycosylated and non-glycosylated forms in human plasma.
View Article and Find Full Text PDFUntargeted Metabolomics and Quantitative Analysis of Tryptophan Metabolites in Myalgic Encephalomyelitis Patients and Healthy Volunteers: A Comparative Study Using High-Resolution Mass Spectrometry.
ACS Chem Neurosci
October 2024
Analytical Chemistry and Neurochemistry, Department of Chemistry─BMC, Uppsala University, Box 599, 751 24 Uppsala, Sweden.
Article Synopsis
- - Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness causing severe fatigue, with no known biological cause identified despite affecting millions globally.
- - A study compared the metabolic profiles of 38 ME/CFS patients to 24 healthy individuals using various biochemical analyses, revealing significant alterations in key metabolic pathways.
- - The results indicated changes in levels of certain substances related to immune response and oxidative stress, suggesting potential biological mechanisms underlying ME/CFS.
Exploring the interplay between kidney function and urinary metabolites in young adults: the African-PREDICT study.
Amino Acids
August 2024
Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.
The exposure to modifiable risk factors at young ages have been linked to premature fatal and non-fatal cardiovascular and kidney outcomes. The use of urinary metabolomics has shown strong predictability of kidney function and cardiovascular disease (CVD). We therefore determined the associations between estimated glomerular filtration rate (eGFR) and urinary metabolites in young adults with and without CVD risk factors.
View Article and Find Full Text PDFThe variation of acrylamide and 5-hydroxymethylfurfural in tea with different roasting degrees and the effects of tea polyphenols on their formation.
J Sci Food Agric
December 2024
State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China.
Background: Roasting is an essential step in making roasted teas, and its role in producing flavors has been widely studied. However, the variation of potential hazardous compounds during the tea roasting process is still vague. The present study established an effective method based on liquid chromatography-triple quadrupole-tandem mass spectrometry to simultaneously determine the variation of acrylamide (AA), 5-hydroxymethylfurfural (5-HMF), and free amino acids during the tea roasting process.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!