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Minimal change disease following autologous stem cell transplant for Hodgkin lymphoma.
BMJ Case Rep
January 2025
Department of Haematology, Northern Health, Epping, Victoria, Australia.
Nephrotic syndrome is characterised by heavy proteinuria secondary to glomerular injury. It is an uncommon but serious complication of allogeneic haematopoietic stem cell transplant (HSCT), but rarely reported after autologous HSCT. Here, we report the case of a man in his mid-20s who presented with significant peripheral oedema 2 months after autologous HSCT for Hodgkin lymphoma.
View Article and Find Full Text PDFDiagnosis and treatment of secondary nephrotic syndrome with rash as the first symptom: a case report.
BMC Nephrol
July 2024
Department of Nephrology, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China.
Background: Membranous nephropathy (MN) is a common type of nephrotic syndrome (NS) in adults, accounting for about 20-30% of cases. Although secondary to specific factors, the coexistence of MN and mantle cell lymphoma (MCL) has been scarcely reported in clinical literature.
Case Presentation: A 59-year-old Chinese male was admitted to the hospital with a generalized pruritic rash with bilateral lower extremity edema, which did not improve significantly after symptomatic treatment.
Minimal Change Nephrotic Syndrome Secondary to Methotrexate-associated Hodgkin Lymphoma.
Intern Med
June 2024
Department of Nephrology, Japanese Red Cross Kyoto Daiichi Hospital, Japan.
The patient was a 64-year-old man who had been receiving methotrexate (MTX) for rheumatoid arthritis for 8 years. Computed tomography (CT) obtained one month prior to admission revealed numerous enlarged lymph nodes. Lower leg edema appeared two weeks prior to admission.
View Article and Find Full Text PDFAdeno-associated virus gene therapy prevents progression of kidney disease in genetic models of nephrotic syndrome.
Sci Transl Med
August 2023
Bristol Renal, Bristol Medical School, Dorothy Hodgkin Building, University of Bristol, Bristol BS1 3NY, UK.
Gene therapy for kidney diseases has proven challenging. Adeno-associated virus (AAV) is used as a vector for gene therapy targeting other organs, with particular success demonstrated in monogenic diseases. We aimed to establish gene therapy for the kidney by targeting a monogenic disease of the kidney podocyte.
View Article and Find Full Text PDFBenign and malignant proliferation in idiopathic nephrotic syndrome: a French cohort study.
Pediatr Nephrol
August 2022
Department of Pediatrics, Pediatric Nephrology Unit, Centre De Référence Des Maladies Rénales Rares du Sud-Ouest, SoRare, Bordeaux University Hospital, Bordeaux, France.
Background: There seems to be a possible link between nephrotic syndrome (NS) and lymphoproliferative syndrome, but it remains poorly understood.
Methods: This multicentric and retrospective study focuses on children, who developed idiopathic NS and malignant or benign proliferation between 2000 and 2021.
Results: Eleven patients were included, with a median age of 4 years.
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