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Functional genomic insights into Floricoccus penangensis ML061-4 isolated from leaf surface of Assam tea.
Sci Rep
January 2025
School of Microbiology, University College Cork, Cork, T12 YT20, Ireland.
Floricoccus penangensis ML061-4 was originally isolated from the leaf surface of an Assam tea plant (Camellia sinensis var. assamica) from Northern Thailand. To assess the functions encoded by the F.
View Article and Find Full Text PDFResponding to exogenous quorum-sensing signals promotes defense against phages by repressing OmpV expression in Pseudomonas syringae pv. actinidiae.
Microbiol Res
January 2025
State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:
Bacteriophages as viral predators can restrict host strains and shape the bacterial community. Conversely, bacteria also adopt diverse strategies for phage defense. Pseudomonas syringae pv.
View Article and Find Full Text PDFActivation and modulation of the host response to DNA damage by an integrative and conjugative element.
J Bacteriol
January 2025
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Mobile genetic elements help drive horizontal gene transfer and bacterial evolution. Conjugative elements and temperate bacteriophages can be stably maintained in host cells. They can alter host physiology and regulatory responses and typically carry genes that are beneficial to their hosts.
View Article and Find Full Text PDFGenome Sequence of Bacteriophage Wheezy.
MicroPubl Biol
January 2025
School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, United States.
Bacteriophage Wheezy, a lytic phage with siphoviral morphology isolated using the host 3612, has a genome of 67,021 base pairs and is 65.9% GC. The genome sequence of Wheezy aligns most closely with subcluster CR2 phages Tracker and NatB6.
View Article and Find Full Text PDFMicroenvironment-confined kinetic elucidation and implementation of a DNA nano-phage with a shielded internal computing layer.
Nat Commun
January 2025
Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Multiple receptor analysis-based DNA molecular computation has been developed to mitigate the off-target effect caused by nonspecific expression of cell membrane receptors. However, it is quite difficult to involve nanobodies into molecular computation with programmed recognition order because of the "always-on" response mode and the inconvenient molecular programming. Here we propose a spatial segregation-based molecular computing strategy with a shielded internal computing layer termed DNA nano-phage (DNP) to program nanobody into DNA molecular computation and build a series of kinetic models to elucidate the mechanism of microenvironment-confinement.
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