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Investigating strategies for creating cross-linked amyloid fibril networks through branching of amyloid growth.
Colloids Surf B Biointerfaces
March 2025
Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, Aarhus C 8000, Denmark. Electronic address:
Hydrogel biomaterials have been extensively explored for applications in medicine, materials science, and the development of functionalized materials. Traditionally, hydrogels were produced using simple polymers, but advancements over recent decades have enabled the use of biological materials such as proteins, peptides, polysaccharides, and even amyloid fibrils. Among these, amyloid-based hydrogels have demonstrated unique advantages, including enhanced cell adhesion and differentiation.
View Article and Find Full Text PDFPlant Defense Peptides: Exploring the Structure-Function Correlation for Potential Applications in Drug Design and Therapeutics.
ACS Omega
March 2025
Department of Biosciences and Technology, School of Science and Environmental Studies, Dr. Vishwanath Karad MIT-World Peace University, Kothrud, Pune, Maharashtra 411038, India.
Defense peptides are part of plants' innate immune system and show widespread occurrence across the plant kingdom. Most of them belong to the category of antimicrobial peptides (AMPs) and act as strong chemical weapons against the biotic stresses that plants encounter. Plant AMP families exhibit remarkably conserved topology, being cysteine-rich with a conserved number of disulfide bridges stabilizing their three-dimensional structure, cationic in nature, and having hydrophobic surfaces.
View Article and Find Full Text PDFPSMA-targeted Small Molecule-Drug Conjugates based on a Post-Prolyl Peptidase Cleavable Linker for the Treatment of Prostate Cancer.
Mol Cancer Ther
March 2025
Philochem AG, Otelfingen, Zurich, Switzerland.
Prostate Specific Membrane Antigen (PSMA) is a transmembrane glycoprotein that is over-expressed on the surface of cancerous prostate cells both in primary tumors and in metastases. Small organic ligands targeting PSMA have been broadly and successfully used to deliver radionuclide payloads to prostate cancer lesions. 177Lu-PSMA-617 (Pluvicto®, a Novartis product) is a PSMA-targeted product that has been recently approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC).
View Article and Find Full Text PDFStereoselective Synthesis of 1,2-cis-α-Glycosyl Thiols and Trehalose-Type α,α'-Thiodisaccharides by Cryo Thiol-Ene Photocoupling - Thio-Click Reaction in Frozen State.
Chemistry
March 2025
Department of Pharmaceutical Chemistry, University of Debrecen, 4032, Debrecen, Egyetem tér 1, Hungary.
α-Glycosyl thiols are key building blocks for the formation of stable thioglycoside mimetics of widespread and biologically relevant α-O-glycosides, which urges their efficient synthesis. Here, we demonstrate that the photoinitiated radical-mediated addition of thioacetic acid to 2-substituted glycals followed by selective S-deacetylation is a generally applicable and fully stereoselective method for the synthesis of 1,2-cis-α-glycosyl thiols. The low reactivity of thioacetic acid in the radical reaction was overcome by carrying out the reaction in AcOH at -80 °C, in frozen state, with UVA irradiation, achieving high yields irrespective of the sugar configurations.
View Article and Find Full Text PDFPhotoisomerization of Azobenzene-Extended Charybdotoxin for the Optical Control of K1.2 Potassium Channel Activity.
Angew Chem Int Ed Engl
February 2025
L'institut du thorax, Nantes Université, CNRS, INSERM, Nantes, F-44000, France.
Natural peptides from animal venoms effectively modulate ion channel activity. While photoswitches regulate small compound pharmacology, their application to natural peptides rich in disulfide bridges and active on ion channels is novel due to larger pharmacophores. A pilot study integrating azobenzene photoswitches into charybdotoxin (ChTx), known for blocking potassium channels is initiated.
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