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The toxic effect of dermotrophic substances in tests in vitro.
J Hyg Epidemiol Microbiol Immunol
March 1988
Institute of Hygiene and Epidemiology, Prague, Czechoslovakia.
In the model system of tissue culture, the effect of dermatotrophic substances, such as the tenzides and conservatory substances, was tested. The cytotoxic effect of the substances was evaluated according to the vitality of the cells and the lactate dehydrogenase (LDH) activity in the suspension culture of human lymphocytes and further according to the migration inhibition of cells from the animal spleen fragments (SF). The cells obtained from rabbits, guinea pigs, mice and man were used.
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