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Cell-type-specific networks during hippocampal seizures at the micro- and macroscale.
Brain
January 2025
Department of Neurology, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China.
Epilepsy is a network disorder, involving neural circuits at both the micro- and macroscale. While local excitatory-inhibitory imbalances are recognized as a hallmark at the microscale, the dynamic role of distinct neuron types during seizures remain poorly understood. At the macroscale, interactions between key nodes within the epileptic network, such as the central median thalamic nucleus (CMT), are critical to the, hippocampal epileptic process.
View Article and Find Full Text PDFArthroscopic Bone Grafting of Deep Acetabular Cysts in Hip Preservation Surgery: A Matched Case-Control Study.
Orthop J Sports Med
January 2025
Department of Orthopedics, School of Medicine, University of Colorado, Aurora, Colorado, USA.
Background: Acetabular subchondral cysts are commonly identified signs of joint degeneration and arthritis. This pathology is generally considered a relative contraindication for hip preservation surgery.
Purpose: To investigate the effect of arthroscopic bone grafting for the treatment of acetabular subchondral cysts.
Huanglian Ejiao Decoction Alleviates Ulcerative Colitis in Mice Through Regulating the Gut Microbiota and Inhibiting the Ratio of Th1 and Th2 Cells.
Drug Des Devel Ther
January 2025
The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.
Background: Huanglian-ejiao decoction (HED) is a Chinese traditional medicinal formula evolved from the Shanghan Lun (Treatise on Febrile Diseases). However, HED ultimate mechanism of action remained indistinct. Therefore, this study aimed to investigate whether HED could exert anti-inflammatory effects on 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis (UC) model through the regulation of CD4T subsets and gut microbiota.
View Article and Find Full Text PDFImpact of Implant Mesiodistal Distance on Peri-Implant Bone Loss: A Cross-Sectional Retrospective Study.
Clin Implant Dent Relat Res
February 2025
Department of Periodontics and Oral Medicine, The University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Purpose: The purpose of this study was to verify the effect of our previously proposed mesiodistal distance for multiple posterior implants on preserving peri-implant bone, and to provide a measurable criterion for predicting implant prognosis.
Methods: One hundred and two patients with dental implants placed in the posterior free-end edentulous arches were recruited in this cross-sectional study. Calibrated X-rays (peri-apical [PA] or bite-wing x-ray) were collected to measure the mesiodistal space as well as the corresponding bone resorption of implants after prosthesis placement.
Exosome-loading miR-205: a two-pronged approach to ocular neovascularization therapy.
J Nanobiotechnology
January 2025
Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China.
Pathological neovascularization is a hallmark of many vision-threatening diseases. However, some patients exhibit poor responses to current anti-VEGF therapies due to resistance and limited efficacy. Recent studies have highlighted the roles of noncoding RNAs in various biological processes, paving the way for RNA-based therapeutics.
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