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Reversal of Roux-en-Y Gastric Bypass: A Multi-Centric Analysis of Indications, Techniques, and Surgical Outcomes.
Obes Surg
January 2025
Department of Surgery and Transplantation, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.
Background: Roux-en-Y gastric bypass may present long-term complications that require revisional surgery or even reversal to normal anatomy. Data on the indications, surgical technique, and outcomes of RYGB reversal remain scarce.
Methods: We identified 48 cases of RYGB reversals with complete 90-day follow-up within a multi-centric international retrospective database of elective secondary bariatric surgery.
Structural changes in the nociceptive system induced by long-term conventional spinal cord stimulation in experimental painful diabetic polyneuropathy.
Reg Anesth Pain Med
November 2024
Department of Anesthesiology and Pain Management, MUMC+, Maastricht, The Netherlands.
Article Synopsis
- Long-term conventional spinal cord stimulation (LT-SCS) is effective for treating painful diabetic peripheral neuropathy (PDPN) initially, but its effectiveness may decline over time.
- *In a rat study, LT-SCS led to increased thresholds for mechanical hypersensitivity and changes in nerve fiber density, indicating structural adaptations in response to pain.
- *The study suggests that LT-SCS reduces certain proteins associated with pain pathways, revealing potential mechanisms for its effectiveness in managing PDPN symptoms.*
European Quality Markers in Oral and Maxillofacial Surgery Specialty Training: Defining Standards.
Br J Oral Maxillofac Surg
November 2024
According to the European Union (EU) Directive 2005/36, the medical specialty of oral and maxillofacial surgery (OMFS) exists with two possible formats: dual degree OMFS called Dental, Oral and Maxillofacial Surgery (DOMFS) - basic medical and basic dental training and single medical degree Maxillofacial Surgery (MFS). Within the EU and across all of Europe, differences in the nature and quality of OMFS training coexist. By implementing the highest possible standards of training, patient care can be improved.
View Article and Find Full Text PDFAssessing the Applicability of Cardiac Myosin Inhibitors for Hypertrophic Cardiomyopathy Management in a Large Single Center Cohort.
Rev Cardiovasc Med
June 2024
Institute for Cardiomyopathies & Center for Cardiogenetics, Department of Medicine III, University of Heidelberg, 69120 Heidelberg, Germany.
Background: Cardiac myosin inhibitors (CMIs), including Mavacamten and Aficamten, have emerged as a groundbreaking treatment for hypertrophic cardiomyopathy (HCM). The results from phase 2 and 3 randomized clinical trials for both drugs have showed promising outcomes. However, the highly selective patient recruitment for these trials raises questions about the generalizability of the observed positive effects across broader patient populations suffering from HCM.
View Article and Find Full Text PDFMachine learning-based preoperative analytics for the prediction of anastomotic leakage in colorectal surgery: a swiss pilot study.
Surg Endosc
July 2024
Clarunis, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, 4002, Basel, Switzerland.
Background: Anastomotic leakage (AL), a severe complication following colorectal surgery, arises from defects at the anastomosis site. This study evaluates the feasibility of predicting AL using machine learning (ML) algorithms based on preoperative data.
Methods: We retrospectively analyzed data including 21 predictors from patients undergoing colorectal surgery with bowel anastomosis at four Swiss hospitals.
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