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Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models.
Sci Transl Med
January 2025
University of Strasbourg, INSERM, Strasbourg Translational Neuroscience & Psychiatry STEP-CRBS, UMR-S 1329, 67000 Strasbourg, France.
Sleep alterations have been described in several neurodegenerative diseases yet are currently poorly characterized in amyotrophic lateral sclerosis (ALS). This study investigates sleep macroarchitecture and related hypothalamic signaling disruptions in ALS. Using polysomnography, we found that both patients with ALS as well as asymptomatic and mutation carriers exhibited increased wakefulness and reduced non-rapid eye movement sleep.
View Article and Find Full Text PDFTrajectory of the arterial-alveolar oxygen gradient in COPD for a decade.
PLoS One
January 2025
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan.
Background: Chronic respiratory failure (CRF) is a critical complication in patients with chronic obstructive pulmonary disease (COPD) and is characterized by an increase in the arterial-alveolar oxygen gradient (A-aDO2). The long-term trajectory and prognostic significance remain unclear. This study aimed to assess the prognostic impact of A-aDO2 and elucidate its trajectory over ten years.
View Article and Find Full Text PDFLoss and memorialization.
Int J Psychoanal
December 2024
Clinical Professor of Psychiatry, Weill Cornell Medical College, New York, USA; Editor Emeritus, The Psychoanalytic Quarterly.
Drawing upon Dana Birksted-Breen's work on temporality, and the contrast which she draws between linear, developmental time, seen as a series of unchanging moments, and bidirectional, process time, which is retranscribed again and again (Birksted-Breen [2003] 2016. "Time and the Apres-Coup." In , edited by D.
View Article and Find Full Text PDFThe Clinical Course of Portopulmonary Hypertension and Outcomes With Endothelin Receptor Antagonist Treatment: Observational Study of Data From the US Organ Procurement and Transplantation Network.
Transplant Direct
March 2024
Actelion Pharmaceuticals Ltd, Janssen Pharmaceutical Company of Johnson and Johnson, Global Epidemiology, Allschwil, Switzerland.
Background: Portopulmonary hypertension (PoPH) occurs in patients with advanced liver disease and can be a contraindication to liver transplant (LT). Improvement of hemodynamic parameters with pulmonary arterial hypertension (PAH) therapies (including endothelin receptor antagonists [ERAs]) may help some patients to become eligible for LT.
Methods: We conducted a retrospective secondary data analysis to describe the clinical course and management of PoPH in patients on a US registry LT waitlist and outcomes in patients receiving an ERA.
Poor sleep quality remains a major challenge among tertiary education students in Ghana: A cross-sectional study in a Ghanaian University.
IBRO Neurosci Rep
June 2025
Department of Medical Laboratory Science, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.
Introduction: Sleep plays a crucial role in health, well-being, and academic performance. Despite the recognized importance of good sleep for students, there is a need for a deeper understanding of the sleep problems faced by university students to inform effective campus support services and interventions. This study aimed to evaluate sleep quality among university students by assessing differences in key sleep parameters between sex and age groups.
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