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The series of diastereomeric peptide derivatives N-benzoyl-D,L-X-N epsilon-benzyloxycarbonyl-L-lysine methyl ester where X = alanyl, valyl, leucyl, phenylalanyl and isoleucyl are submitted as model systems for studying racemization in peptide synthesis. The diastereomers can be analyzed by quantitation of the separated ester methyl proton peaks of their nuclear magnetic resonance spectra. Data on the tendency to racemize of the different residues are presented. In polar solvents, valyl and isoleucyl residues racemize more readily than the other residues.
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| http://dx.doi.org/10.1111/j.1399-3011.1979.tb01899.x | DOI Listing |
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