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Effects of vitamin D3, omega-3s, and a simple strength training exercise program on bone health: the DO-HEALTH randomized controlled trial.
J Bone Miner Res
July 2024
Department of Geriatric Medicine and Aging Research, University of Zurich, Zurich 8037, Switzerland.
Article Synopsis
- A study examined the effects of vitamin D3, omega-3s, and a home-based exercise program (SHEP) on bone mineral density (BMD) in healthy older adults aged 70 and above over three years.
- Results showed no significant benefits from omega-3s or SHEP, but vitamin D3 improved total hip BMD and lumbar spine BMD in men with modest gains.
- While there were some positive effects of vitamin D treatment, the overall clinical significance of these findings remains uncertain.
Performance evaluation of machine-assisted interpretation of Gram stains from positive blood cultures.
J Clin Microbiol
April 2024
Division of Human Microbiology, Centre for Laboratory Medicine, St. Gall, Switzerland.
Manual microscopy of Gram stains from positive blood cultures (PBCs) is crucial for diagnosing bloodstream infections but remains labor intensive, time consuming, and subjective. This study aimed to evaluate a scan and analysis system that combines fully automated digital microscopy with deep convolutional neural networks (CNNs) to assist the interpretation of Gram stains from PBCs for routine laboratory use. The CNN was trained to classify images of Gram stains based on staining and morphology into seven different classes: background/false-positive, Gram-positive cocci in clusters (GPCCL), Gram-positive cocci in pairs (GPCP), Gram-positive cocci in chains (GPCC), rod-shaped bacilli (RSB), yeasts, and polymicrobial specimens.
View Article and Find Full Text PDFPrevalence and incidence of iron deficiency in European community-dwelling older adults: an observational analysis of the DO-HEALTH trial.
Aging Clin Exp Res
September 2022
Center on Aging and Mobility, University Hospital Zurich, Zurich City Hospital-Waid and University of Zurich, Zurich, Switzerland.
Background And Aim: Iron deficiency is associated with increased morbidity and mortality in older adults. However, data on its prevalence and incidence among older adults is limited. The aim of this study was to investigate the prevalence and incidence of iron deficiency in European community-dwelling older adults aged ≥ 70 years.
View Article and Find Full Text PDFEffects of vitamin D, omega-3 fatty acids, and a simple home strength exercise program on fall prevention: the DO-HEALTH randomized clinical trial.
Am J Clin Nutr
May 2022
Centre on Aging and Mobility, University of Zurich and City Hospital Zurich, Waid, Zurich, Switzerland.
Background: The roles of vitamin D, omega-3 fatty acids, and home exercise on fall prevention among generally healthy and active older adults are unclear.
Objectives: We tested the effects of daily supplemental vitamin D, daily supplemental marine omega-3s fatty acids, and a simple home exercise program (SHEP), alone or in combination, on the incidences of total and injurious falls among generally healthy older adults.
Methods: We performed a 2 × 2 × 2 factorial-design randomized controlled trial among 2157 community-dwelling adults aged 70 years and older, who had no major health events in the 5 years prior to enrolment, recruited from Switzerland, Germany, Austria, France, and Portugal between December 2012 and November 2014.
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