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Signal Transduction of Constitutive Activating and Inactivating Eel Lutropin/Choriogonadotropin Receptor (Eel LH/CGR) Mutants by Recombinant Equine Chorionic Gonadotropin (Rec-eCG).
Dev Reprod
December 2024
Carbon-Neutral Resources Research Center, Institute of Genetic Engineering, Hankyong National University, Anseong 17579, Korea.
Lutropin/choriogonadotropin receptor (LH/CGR) is a member of the G protein-coupled receptor superfamily. LH/CGRs in fish and mammalian species have been reported to contain naturally occurring, constitutively activating, and inactivating mutations in highly conserved regions. The present study was designed to determine the functional aspect of eel LH/CGR signal transduction.
View Article and Find Full Text PDFDiphtheria antitoxin treatment: from pioneer to neglected.
Mem Inst Oswaldo Cruz
January 2025
Institut Pasteur, Université Paris Cité, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France.
Diphtheria, a severe respiratory infection, was a major killer of children until the early years of the 20th century. Although diphtheria is now largely controlled globally thanks to vaccination, it is still endemic in some world regions and large epidemics can occur where vaccination coverage is insufficient. The pathological effects caused by its main virulence factor, diphtheria toxin, can be diminished by passive transfer of antibodies.
View Article and Find Full Text PDFUveitis and blindness in a closed herd of Equidae following leptospiral infection.
Front Vet Sci
January 2025
Department of Clinical Sciences, North Carolina State University, Raleigh, NC, United States.
Objective: To describe the ocular findings, chronology of disease, and serum leptospiral titers in a group of horses, mules, and donkeys following an outbreak of leptospirosis.
Methods: Fifty Equidae in central North Carolina had ophthalmic examinations and serum leptospiral microscopic agglutination test (MAT) titers performed every 3-6 months for 24 months followed by a final examination at 34 months.
Results: Throughout the nearly three-year study period, 17 horses (34%; 17/49 horses) developed signs of uveitis; 20 eyes (20/34; 58.
Neuropathology, pathomechanism, and transmission in zoonotic Borna disease virus 1 infection: a systematic review.
Lancet Infect Dis
January 2025
Department of Neuropathology, Medical Faculty, University of Augsburg, Augsburg, Germany; Pathology, Medical Faculty, University of Augsburg, Augsburg, Germany. Electronic address:
Borna disease, which is a severe encephalitis that primarily affects horses and sheep, has been recognised for over two centuries. Borna disease virus 1 (BoDV-1) has been identified as a cause of a predominantly fatal encephalitis in humans. Little scientific data exist regarding the virus' transmission, entry portal, and excretion routes.
View Article and Find Full Text PDFChanges in pressure distribution of the solar surface after a single trimming event are associated with external hoof measurements in the equine fore foot.
Equine Vet J
January 2025
Department of Equine Clinical Science, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, UK.
Background: Trimming is critical for a functioning equine hoof. Pressure distribution provides information on loading; however, information on the effects of trimming on pressure distribution is lacking.
Objectives: To describe the pressure changes of equine fore feet following trimming.
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