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Prevalence of Potentially Inappropriate Medications in Older Adults with Cognitive Impairment or Dementia Attending Memory Clinics: A Systematic Review and Meta-Analysis.
J Alzheimers Dis
October 2024
School of Pharmacy, University of Waterloo, Kitchener, Ontario, Canada.
Article Synopsis
- Older adults with dementia on multiple medications are at a higher risk for using potentially inappropriate medications (PIM), which can result in serious health issues.
- A systematic review analyzed 11 studies with over 4,500 participants, finding that approximately 38% of these older adults were using PIMs, with certain medications like anticholinergics and benzodiazepines being the most common culprits.
- The study noted significant variability in PIM prevalence based on the definition used and location, indicating the need for standardized criteria in future research.
Multidisciplinary Effort Leading to Effective Tuberculosis Community Outbreak Containment in Israel.
Microorganisms
August 2024
Department of Tuberculosis and AIDS, Ministry of Health, Jerusalem 9438317, Israel.
Tuberculosis (TB) is the second-most prevalent cause of mortality resulting from infectious diseases worldwide. It is caused by bacteria belonging to the Mycobacterium tuberculosis complex (MTBC). In Israel, TB incidence is low, acknowledged by the WHO as being in a pre-elimination phase.
View Article and Find Full Text PDFPrescription Precision: A Comprehensive Review of Intelligent Prescription Systems.
Curr Pharm Des
October 2024
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Shree S.K. Patel College of Pharmaceutical Education & Research, Ganpat University, Gujarat, India.
Intelligent Prescription Systems (IPS) represent a promising frontier in healthcare, offering the potential to optimize medication selection, dosing, and monitoring tailored to individual patient needs. This comprehensive review explores the current landscape of IPS, encompassing various technological approaches, applications, benefits, and challenges. IPS leverages advanced computational algorithms, machine learning techniques, and big data analytics to analyze patient-specific factors, such as medical history, genetic makeup, biomarkers, and lifestyle variables.
View Article and Find Full Text PDFMeldonium Supplementation in Professional Athletes: Career Destroyer or Lifesaver?
Cureus
July 2024
Biochemistry, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology, Târgu Mureș, ROU.
Meldonium is a substance with known anti-anginal effects demonstrated by numerous studies and human clinical trials; however, it does not possess marketing authorization within the European Union, only in ex-Soviet republics. Since 2016, meldonium has been included by the World Anti-doping Agency (WADA) on the S4 list of metabolic modulators. In performance athletes, meldonium is now considered a doping agent due to its capacity to decrease lactate production during and after exercise, its capability to enhance the storage and utilization of glycogen, and its protective action against oxidative stress.
View Article and Find Full Text PDFRat Model of Isoproterenol-Induced Myocardial Injury.
Methods Mol Biol
April 2024
Department of Pharmacology, Indo-Soviet Friendship College of Pharmacy, Moga, Punjab, India.
Article Synopsis
- Isoproterenol (ISO) causes major biochemical and tissue changes in the heart, resulting in oxidative stress and inflammation that worsen heart injury.
- Administering ISO to rats mimics aspects of human heart disease, helping researchers understand disease mechanisms and test new treatments.
- The chapter discusses how varying dosages and methods of ISO injection can be used to create different levels of heart injury for experimental purposes.
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