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Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago.
World J Emerg Surg
April 2024
Emergency and Trauma Surgery, Bufalini Hospital, Cesena, Italy.
Article Synopsis
- This study compares two surgical methods, Hartmann's procedure (HP) and resection with primary anastomosis (RPA), for treating acute left-sided colonic emergencies among 1215 patients from 204 centers globally.
- Results showed that while HP was the more common treatment (57.3%), RPA was favored for younger patients with fewer health issues and those needing surgery sooner.
- The study concluded that although HP is still widely used, RPA might be the better option, emphasizing the importance of patient characteristics and surgeon experience in determining treatment choice.
Incidence and predictors of post-thrombotic syndrome in patients with proximal DVT in a real-world setting: findings from the GARFIELD-VTE registry.
J Thromb Thrombolysis
February 2024
Thrombosis Research Institute, London, UK.
Although substantial progress has been made in the pathophysiology and management of the post-thrombotic syndrome (PTS), several aspects still need clarification. Among them, the incidence and severity of PTS in the real world, the risk factors for its development, the value of patient's self-evaluation, and the ability to identify patients at risk for severe PTS. Eligible participants (n = 1107) with proximal deep-vein thrombosis (DVT) from the global GARFIELD-VTE registry underwent conventional physician's evaluation for PTS 36 months after diagnosis of their DVT using the Villalta score.
View Article and Find Full Text PDFNew-onset atrial fibrillation and chronic coronary syndrome in the CLARIFY registry.
Eur Heart J
February 2024
Department of Cardiology, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, French Alliance for Cardiovascular Trials, INSERM U1148, Laboratory for Vascular Translational Science, 46 rue Henri Huchard, 75018 Paris, France.
Background And Aims: Data on new-onset atrial fibrillation (NOAF) in patients with chronic coronary syndromes (CCS) are scarce. This study aims to describe the incidence, predictors, and impact on cardiovascular (CV) outcomes of NOAF in CCS patients.
Methods: Data from the international (45 countries) CLARIFY registry (prospeCtive observational LongitudinAl RegIstry oF patients with stable coronary arterY disease) were used.
Effects of Standard-Dose Prophylactic, High-Dose Prophylactic, and Therapeutic Anticoagulation in Patients With Hypoxemic COVID-19 Pneumonia: The ANTICOVID Randomized Clinical Trial.
JAMA Intern Med
June 2023
Université Paris Est Créteil, Institut Mondor de Recherche Biomédicale, Groupe de Recherche Clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis), Créteil, France.
Article Synopsis
- The study focused on determining the best type of anticoagulation therapy for COVID-19 pneumonia patients to reduce mortality and disease duration, comparing therapeutic anticoagulation (TA), high-dose prophylactic anticoagulation (HD-PA), and standard-dose prophylactic anticoagulation (SD-PA).
- Conducted in France, the ANTICOVID trial involved 334 patients with hypoxemic COVID-19 pneumonia, all requiring supplemental oxygen, and aimed to understand the effects of these treatments over a 14-day period.
- Results indicated that HD-PA and SD-PA had similar outcomes, as did TA when compared to SD-PA, suggesting no significant advantage for either anticoagulation strategy in improving patient outcomes by day
Elevated levels of circulatory follicular T helper cells in chronic lymphocytic leukemia contribute to B cell expansion.
J Leukoc Biol
March 2023
Immunoconcept, CNRS UMR 5164, Université de Bordeaux, 146 rue Leo Saignat, 33076 Bordeaux, France.
Article Synopsis
- * The study found increased levels of follicular helper T cells (Tfh) in untreated CLL patients, which were linked to more severe disease, as indicated by the Binet staging system.
- * Tfh cells in CLL patients showed an activated Th1-like phenotype and were found to promote B-CLL cell survival and proliferation through IL-21, while also showing an association with immune dysfunction in CLL, as suggested by the relationship with serum IgA and IgG levels.
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