Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1378/chest.63.1.9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clinical Toxicology of OTC Cough and Cold Pediatric Medications: A Narrative Review.
Pediatric Health Med Ther
July 2024
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Padjadjaran. University, Sumedang, West Java, 45363, Indonesia.
Article Synopsis
- Cough and cold symptoms in children are typically treated with over-the-counter medications, but there's a lack of adequate knowledge about their safety and potential toxicity in this age group.!* -
- The review emphasizes the need for clinical toxicology to assess the safety profiles of these medications, which often contain multiple active ingredients that can lead to serious adverse effects and overdoses.!* -
- Case studies indicate that misuse of OTC cough and cold medications can result in significant toxicity and even fatalities, highlighting the need for informed medical practices and public health policies to protect children's health.!*
Urinary non-targeted toxicokinetics and metabolic fingerprinting of exposure to 3-monochloropropane-1,2-diol and glycidol from refined edible oils.
Food Res Int
February 2022
National Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, Zhejiang, China. Electronic address:
The widespread presence of 3-monochloropropane-1,2-diol (3-MCPD) and glycidol in refined edible oils have raised food industrial and public health concerns, but their specific biomarkers of exposure and urinary metabolic pathways indicating nephrotoxicity remain largely unknown. Here, we unraveled the in vivo biotransformation of these two contaminants and revealed how they affect metabolic pathways in rats. Urine metabolomes in rats administered with glycidol or 3-MCPD were investigated using ultra-high performance liquid chromatography combined with a quadrupole-orbitrap high-resolution mass spectrometry.
View Article and Find Full Text PDFCorrelation between the solid state of lipid coating and release profile of API from hot melt coated microcapsules.
Int J Pharm
June 2019
Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, University of Graz, Graz, Austria.
Solvent-free hot melt coating (HMC) provides a safer and more economic process compared to the conventional solvent coating techniques. However, drug release instability and the lack of fundamental understanding on it are limiting factors for application of HMC for industrial productions. In this work, we investigated glyceryl dibehenate, glyceryl monostearate and behenoyl polyoxyl-8 glyceride as HMC materials.
View Article and Find Full Text PDFAntidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures.
Neurotox Res
August 2014
Department of Toxicology, Faculty of Pharmacy, College of Medicum, Jagiellonian University, 9, Medyczna Street, 30-688, Kraków, Poland,
The endocannabinoid (eCB) system has recently been implicated in both the pathogenesis of depression and the action of antidepressants. Here, we investigated the effect of acutely or chronically administering antidepressants [imipramine (IMI) (15 mg/kg), escitalopram (ESC) (10 mg/kg), and tianeptine (10 mg/kg)] on the levels of both eCBs [anandamide (AEA) and 2-arachidonoylglycerol (2-AG)] and N-acylethanolamines (NAEs) [palmitoylethanolamide (PEA) and oleoylethanolamide (OEA)] in various rat brain regions. We also examined the ability of the acute and chronic administration of N-acetylcysteine (NAC) (a mucolytic drug; 100 mg/kg) or URB597 (a fatty acid amide hydrolase inhibitor; 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!