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Tumor-Infiltrating Lymphocytes in Patients With Stage I Triple-Negative Breast Cancer Untreated With Chemotherapy.
JAMA Oncol
August 2024
Division of Tumor Biology and Immunology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.
Importance: The absolute benefit of chemotherapy for all patients with stage I triple-negative breast cancer (TNBC) is unclear, and biomarkers are not currently available for selecting patients with an excellent outcome for whom neoadjuvant or adjuvant chemotherapy may have negligible benefit. High levels of stromal tumor-infiltrating lymphocytes (sTILs) are associated with favorable survival in TNBC, but data solely in stage I TNBC are lacking.
Objective: To examine the outcomes of patients of all ages with stage I TNBC solely and who received neither neoadjuvant nor adjuvant chemotherapy, according to centrally reviewed sTIL levels at prespecified cutoffs.
Essential requirements for reporting radiation therapy in breast cancer clinical trials: An international multi-disciplinary consensus endorsed by the European Society for Radiotherapy and Oncology (ESTRO).
Radiother Oncol
June 2024
Department of Experimental Clinical Oncology, Danish Centre for Particle Therapy, Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
The European Society for Radiotherapy and Oncology (ESTRO) has advocated the establishment of guidelines to optimise precision radiotherapy (RT) in conjunction with contemporary therapeutics for cancer care. Quality assurance in RT (QART) plays a pivotal role in influencing treatment outcomes. Clinical trials incorporating QART protocols have demonstrated improved survival rates with minimal associated toxicity.
View Article and Find Full Text PDFSafety Surveillance During Drug Development: Comparative Evaluation of Existing Regulations.
Adv Ther
May 2023
Global Safety Writing & Medical Services, UBC, Vernier, Geneva, Switzerland.
Drug safety monitoring is essential for developing efficient and safe treatments. It starts with preclinical toxicology studies and continues with the observation and analysis of potentially harmful effects in humans throughout the whole drug life cycle. Safety surveillance during the clinical phase is of paramount importance for protecting the health of clinical trial (CT) participants at a period when relatively little is known about the drug safety profile, and for reassuring that detected risks are minimized when the product obtains marketing approval.
View Article and Find Full Text PDFEditorial: Sarcopenia: Keeping on Search for the Best Operational Definition.
J Nutr Health Aging
March 2023
Professor Yves Rolland, MD, PhD, Gérontopôle de Toulouse, Institut du Vieillissement, 37 allées Jules Guesdes, 31000 Toulouse, France, + 33 5 61 70 77 21, E-mail:
The Management of Lumps, Bumps, and Contour Irregularities of the Lower Eyelid and Cheek After Poor Outcome Fat Transfer.
Aesthet Surg J
May 2023
Oculoplastic surgeons, Cedars-Sinai Medical Centre, Los Angeles, CA, USA.
Background: The increasing popularity of fat transfer (FT) to the lower eyelids has led to an increase in unwanted lumps, bumps, and contour irregularities (LBCs). Few studies have addressed the management of LBCs.
Objectives: The aim of this study was to address the management of LBCs.
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