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Pepsinogen C Interacts with IQGAP1 to Inhibit the Metastasis of Gastric Cancer Cells by Suppressing Rho-GTPase Pathway.
Cancers (Basel)
May 2024
Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang 110001, China.
Aim: This study systematically explored the biological effects and mechanisms of PGC on gastric cancer (GC) cells in vitro and in vivo.
Method: The critical biological roles of PGC in GC were assessed via EdU staining, Hoechst staining, flow cytometry, mouse models, CCK-8, wound healing, transwell, and sphere-forming assays. The interaction study with IQ-domain GTPase-activating protein 1 (IQGAP1) was used by Liquid chromatography-mass spectrometry co-immunoprecipitation, immunofluorescence staining, CHX-chase assay, MG132 assay, and qRT-PCR.
Weierning, a Chinese patent medicine, improves chronic atrophic gastritis with intestinal metaplasia.
J Ethnopharmacol
June 2023
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Zhejiang, Hangzhou, 310053, China. Electronic address:
Ethnopharmacological Relevance: Weierning tablet (WEN) is a traditional Chinese patent medicine widely used in clinical for chronic atrophic gastritis (CAG) therapy for years. However, the underlying mechanisms of WEN on anti-CAG are still unveiled.
Aim Of The Study: The present study aimed to elucidate the characteristic function of WEN on anti-CAG and to illuminate its potential mechanism.
Activation of dopamine D receptor promotes pepsinogen secretion by suppressing somatostatin release from the mouse gastric mucosa.
Am J Physiol Cell Physiol
March 2022
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, People's Republic of China.
In vivo administration of dopamine (DA) receptor (DR)-related drugs modulate gastric pepsinogen secretion. However, DRs on gastric pepsinogen-secreting chief cells and DA D receptor (DR) on somatostatin-secreting D cells were subsequently acquired. In this study, we aimed to further investigate the local effect of DA on gastric pepsinogen secretion through DRs expressed on chief cells or potential DRs expressed on D cells.
View Article and Find Full Text PDFInduction of Gastric Cancer by Successive Oncogenic Activation in the Corpus.
Gastroenterology
December 2021
Cancer Science Institute of Singapore, National University of Singapore, Singapore. Electronic address:
Background & Aims: Metaplasia and dysplasia in the corpus are reportedly derived from de-differentiation of chief cells. However, the cellular origin of metaplasia and cancer remained uncertain. Therefore, we investigated whether pepsinogen C (PGC) transcript-expressing cells represent the cellular origin of metaplasia and cancer using a novel Pgc-specific CreERT2 recombinase mouse model.
View Article and Find Full Text PDFInterrelation secretory activity of stomach and immunes changes of peripheral blood when ulcerogenesis stomach.
Patol Fiziol Eksp Ter
January 2018
Unlabelled: Incidence of gastric ulcer is high in almost all countries of the world. On the development and course of the disease affect the state acid- and enzymes production stomach, immune status. The purpose was to determine the presence and power of correlative links secretory activity of the stomach and immune changes in the peripheral blood during exacerbation of ulcer disease stomach.
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