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Multiple gastric neuroendocrine tumors in a patient with parietal cell dysfunction and adenosine triphosphatase H/K transporting subunit alpha gene variant.
Clin J Gastroenterol
August 2024
Faculty of Medicine, Department of Gastroenterology, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
A 47-year-old woman presented with multiple gastric tumors, each up to 10 mm in diameter, in the gastric body and fundus without mucosal atrophy. White spots and numerous transparent, light-brownish, small, and rounded spots were observed in the background gastric mucosa. Biopsy specimens obtained from the tumors revealed gastric neuroendocrine tumors.
View Article and Find Full Text PDFA Case of Severe Hypocalcemia Caused by Malabsorption Due to Partial Gastrectomy and Small Bowel Resection.
AACE Clin Case Rep
April 2021
Division of Endocrinology, Metabolism, and Lipids, Department of Internal Medicine, Emory University School of Medicine, Atlanta, Georgia.
Objective: Calcium is an essential mineral involved in the functioning of nearly every human cell. Calcium levels are regulated by dietary absorption, vitamin D status, and parathyroid hormone (PTH). This report describes a patient in whom childhood bowel resection and partial gastrectomy resulted in malabsorptive hypocalcemia in adulthood.
View Article and Find Full Text PDFSmall Intestinal Bacterial Overgrowth: A Critical Review of an Underrecognized but Disrupting Entity.
Crit Rev Oncog
November 2021
Department of Gynecologic Oncology, AdventHealth Cancer Institute, Orlando, FL 32804.
Small intestinal bacterial overgrowth (SIBO) is a common gastrointestinal (GI) problem, but its diagnosis is often missed in the clinical setting. Because its diagnosis mostly requires invasive testing, often its true prevalence is unknown. Commonly presenting complaints include abdominal distension, diarrhea, and malabsorption.
View Article and Find Full Text PDFNetazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors.
Cell Mol Gastroenterol Hepatol
May 2021
Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom; Liverpool University Hospitals, National Health Service Foundation Trust, Liverpool, United Kingdom. Electronic address:
Background & Aims: In patients with autoimmune atrophic gastritis and achlorhydria, hypergastrinemia is associated with the development of type 1 gastric neuroendocrine tumors (gNETs). Twelve months of treatment with netazepide (YF476), an antagonist of the cholecystokinin B receptor (CCKBR or CCK2R), eradicated some type 1 gNETs in patients. We investigated the mechanisms by which netazepide induced gNET regression using gene expression profiling.
View Article and Find Full Text PDFHunger and microbiology: is a low gastric acid-induced bacterial overgrowth in the small intestine a contributor to malnutrition in developing countries?
Microb Biotechnol
September 2017
Nutrition and Health Institute, Gut Ecosystem Department, Host- Microbe Interaction Group, Nestlé Research Centre, CH-1000, Lausanne 26, Switzerland.
Underproduction of hydrochloric acid into the stomach is frequently encountered in subjects from developing countries. We explore the hypothesis that hypochlorhydria compromises the gastric barrier and favours bacterial overgrowth in the proximal parts of the small intestine where nutrient absorption takes place. Food calories are thus deviated into bacterial metabolism.
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