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Aortic Valve Plasty for Coexistence of Discrete Subvalvular Aortic Stenosis and Quadricuspid Aortic Valve: A Case Report.
Cureus
December 2024
Cardiovascular Surgery, Ayase Heart Hospital, Tokyo, JPN.
Subvalvular aortic stenosis typically manifests at a young age and rarely presents in adulthood. It may cause left ventricular outflow tract stenosis, which requires surgical treatment in severe cases. The coexistence of discrete subvalvular aortic stenosis and quadricuspid aortic valve is a highly unusual finding.
View Article and Find Full Text PDFThe proteomic response of to amphotericin B (AmB) reveals the involvement of the RTA-like protein RtaA in AmB resistance.
Microlife
December 2024
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Adolf-Reichwein-Str. 23, 07745 Jena, Germany.
The polyene antimycotic amphotericin B (AmB) and its liposomal formulation AmBisome belong to the treatment options of invasive aspergillosis caused by . Increasing resistance to AmB in clinical isolates of species is a growing concern, but mechanisms of AmB resistance remain unclear. In this study, we conducted a proteomic analysis of exposed to sublethal concentrations of AmB and AmBisome.
View Article and Find Full Text PDFProbing non-peptide agonists binding at the human nociceptin/orphanin FQ receptor: a molecular modelling study.
RSC Med Chem
December 2024
Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara 44121 Ferrara Italy
The N/OFQ-NOP receptor is a fascinating peptidergic system with the potential to be exploited for the development of analgesic drugs devoid of side effects associated with classical opioid signalling modulation. To date, up to four X-ray and cryo-EM structures of the NOP receptor in complex with the endogenous peptide agonist N/OFQ and three small molecule antagonists have been solved and released. Despite the available structural information, the details of selective small molecule agonist binding to the NOP receptor in the active state remain elusive.
View Article and Find Full Text PDFInferring structure of cortical neuronal networks from activity data: A statistical physics approach.
PNAS Nexus
January 2025
Department of Mathematics, Aston University, Birmingham B4 7ET, United Kingdom.
Understanding the relation between cortical neuronal network structure and neuronal activity is a fundamental unresolved question in neuroscience, with implications to our understanding of the mechanism by which neuronal networks evolve over time, spontaneously or under stimulation. It requires a method for inferring the structure and composition of a network from neuronal activities. Tracking the evolution of networks and their changing functionality will provide invaluable insight into the occurrence of plasticity and the underlying learning process.
View Article and Find Full Text PDFPlatinum-Nickel@High-Entropy Alloy Core@Satellite Nanowires as Efficient Bifunctional Electrocatalysts for PEMFC.
Nano Lett
January 2025
College of Energy, Xiamen University, Xiamen 361102, China.
The optimized composition and precisely tailored structure configuration play critical roles in enhancing the catalytic reaction kinetics. Here we report a distinctive core@satellite strategy for designing the advanced platinum-nickel@platinum-nickel-copper-cobalt-indium high-entropy alloy nanowires (PtNi@HEA NWs) as efficient bifunctional catalysts in the proton exchange membrane fuel cell. Impressively, the PtNi@HEA NWs/C shows 19.
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