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A synthesis of the patho-physiology of Mycobacterium avium subspecies paratuberculosis infection in sheep to inform mathematical modelling of ovine paratuberculosis.
Vet Res
March 2018
Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
This literature review of exposure to Mycobacterium avium subsp. paratuberculosis (MAP) in sheep enabled a synthesis of the patho-physiology of ovine paratuberculosis (PTB). These results could be used to inform subsequent modelling of ovine PTB.
View Article and Find Full Text PDFBayesian analysis improves pulse secretion characterization in reproductive hormones.
Syst Biol Reprod Med
February 2018
c Department of Biostatistics and Informatics , Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora , CO , USA.
Unlabelled: Pulsatile secretion of hormones in the hypothalamic-pituitary-gonadal axis is critical for normal functioning of the reproductive system. Thus, appropriate characterization of pulsatile secretion is important for identifying the (patho)physiology of reproductive conditions. Existing analysis methods often fail to adequately characterize pulsatility, especially when the signal-to-noise ratio is low.
View Article and Find Full Text PDFMammary stem cell research in veterinary science: an update.
Stem Cells Dev
June 2013
Department of Comparative Physiology and Biometrics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
The mammary gland is an organ with a remarkable regenerative capacity that can undergo multiple cycles of proliferation, lactation, and involution. Growing evidence suggests that these changes are driven by the coordinated division and differentiation of mammary stem cell populations (MaSC). Whereas information regarding MaSC and their role in comparative mammary gland physiology is readily available in human and mice, such information remains scarce in most veterinary mammal species such as cows, horses, sheep, goats, pigs, and dogs.
View Article and Find Full Text PDFCharacterization and modeling of the peripheral cardiac conduction system.
IEEE Trans Med Imaging
January 2013
Computational Multiscale Physiology Laboratory (CoMMLab), Department of Computer Science, Universitat de Valencia, 46100 Valencia, Spain.
The development of biophysical models of the heart has the potential to get insights in the patho-physiology of the heart, which requires to accurately modeling anatomy and function. The electrical activation sequence of the ventricles depends strongly on the cardiac conduction system (CCS). Its morphology and function cannot be observed in vivo, and therefore data available come from histological studies.
View Article and Find Full Text PDFMolecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury.
Am J Physiol Lung Cell Mol Physiol
March 2010
Investigational Intensive Care Unit, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA.
Neuronal nitric oxide synthase is critically involved in the pathogenesis of acute lung injury resulting from combined burn and smoke inhalation injury. We hypothesized that 7-nitroindazole, a selective neuronal nitric oxide synthase inhibitor, blocks central molecular mechanisms involved in the pathophysiology of this double-hit insult. Twenty-five adult ewes were surgically prepared and randomly allocated to 1) an uninjured, untreated sham group (n = 7), 2) an injured control group with no treatment (n = 7), 3) an injury group treated with 7-nitroindazole from 1-h postinjury to the remainder of the 24-h study period (n = 7), or 4) a sham-operated group subjected only to 7-nitroindazole to judge the effects in health.
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