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A simple acetylcholinesterase inhibition assay for the quantification of the nerve agent VX: Application in a Franz cell model with rat skin and various decontaminants.
Toxicol Lett
January 2025
Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany; Walther-Straub-Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Goethestrasse 33, 80336 Munich, Germany. Electronic address:
The medical community continues to regard organophosphate nerve agent poisoning as a significant concern. Due to the lack of therapeutic options for the nicotinic signs and symptoms for certain agents (e.g.
View Article and Find Full Text PDFA novel method for the rapid determination of phenolic compounds based on the nanozyme with laccase-like activity.
Environ Res
January 2025
Key Laboratory of Groundwater Resources and Environment (Jilin University), Ministry of Education, College of New Energy and Environment, Jilin University, Changchun 130021, P. R. China; Jilin Provincial Key Laboratory of Water Resources and Water Environment, College of New Energy and Environment, Jilin University, Changchun 130021, P. R. China. Electronic address:
Phenolic compounds are prevalent in domestic and industrial effluents, leading a serious environmental hazard. Paper-based analysis device mediated by nanozymes has shown great potential in portable visual determination of phenolic compounds in the environment. In this work, we used nicotinic acid derivatives such as pyridine-2,3-dicarboxylic acid, 2-methylnicotinic acid and 2-aminonicotinic acid by coordinating copper (II) acetate monohydrate coordination to obtain Cu2-COOHNA, Cu2-CHNA, Cu2-ANA nanozymes with laccase-activity.
View Article and Find Full Text PDFSynthesis of harmaline N-9 derivatives and investigation of in vitro anticancer activity.
Bioorg Med Chem Lett
January 2025
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488 China. Electronic address:
Harmaline as a natural compound possessed a wide range of pharmacological activities. In this study, 22 novel harmaline-based derivatives were synthesized and screened for in vitro anti-proliferation activity against three cancer cell lines, HCT116, MCF7, and MGC803. The modification site was at the position N-9 of harmaline.
View Article and Find Full Text PDFImpaired lipid homeostasis and elevated lipid oxidation of erythrocyte membrane in adolescent depression.
Redox Biol
January 2025
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China; Shanghai Mental Health Center, Shanghai Key Laboratory of Psychiatry Disorders, Shanghai Jiao Tong University, Shanghai, China. Electronic address:
Adolescent depression is a globally concerned mental health issue, the pathophysiological mechanisms of which remain elusive. Membrane lipids play a crucial role in brain development and function, potentially serving as a crossroad for the abnormalities in neurotransmitters, neuroendocrine, inflammation, oxidative stress, and energy metabolism observed in depressed adolescents. The primary aim of this study was to investigate the erythrocyte membrane lipid profile in adolescent depression.
View Article and Find Full Text PDFCharacterization of cell membrane fragments containing muscle type nAChR from Tetronarce californica after preparation using high pressure homogenization.
Toxicol Lett
January 2025
Bundeswehr Institute for Pharmacology and Toxicology, Neuherbergstraße 11, 80937 Munich, Germany. Electronic address:
The nicotinic acetylcholine receptor (nAChR) is a pentameric ligand-gated ion channel (pLGIC) commonly used as a model for receptors belonging to the Cys-loop superfamily. Members of pLGICs are standardly used in numerous toxicological investigations e.g.
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