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Topical Cenegermin-Bkbj Dramatically Resolves Neurotrophic Keratitis Associated With Pars Plana Vitrectomy.
Ophthalmic Surg Lasers Imaging Retina
March 2025
Neurotrophic keratitis (NK) may occur secondary to pars plana vitrectomy (PPV). A subset of patients with very severe NK corneal defects may require therapy escalation, and Cenegermin-Bkbj, a recombinant human nerve growth factor, represents a novel treatment option. This case report presents the successful treatment of refractory NK using Cenegermin-Bkbj in a patient after undergoing multiple PPV surgeries.
View Article and Find Full Text PDFConcurrent Descemet Stripping Only With Excision of Iris Pigment Epithelial Cysts.
Cornea
March 2025
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; and.
Purpose: To describe a case of bilateral large iris pigment epithelial (IPE) cysts causing corneal endothelial dysfunction that was successfully managed with a surgical cyst excision combined with Descemet stripping only (DSO) procedure followed by postoperative rho kinase inhibitor (ROCK-I) administration.
Methods: Case report.
Results: A 27-year-old woman presented with bilateral large IPE cysts adhering to the corneal endothelium, causing endothelial dysfunction with overlying corneal edema.
Navigating Retinal Complications and Refractive Outcomes in High Myopia: A Case Report With Multi-surgical Interventions.
Cureus
February 2025
Department of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, POL.
Refraction through the ocular system is the process of bending light rays within the eye's optical system, which includes the cornea, anterior chamber, lens, and vitreous body. These structures work together to ensure precise focusing of light on the retina, enabling clear vision. Dysfunction or pathology at any level of the optical system can significantly affect the quality of vision, leading to changes in refractive status and visual acuity disturbances.
View Article and Find Full Text PDFSimultaneous conjunctival melanomas in one eye treated with both adjuvant brachytherapy and proton beam radiotherapy.
Am J Ophthalmol Case Rep
June 2025
Department of Ophthalmology, University of Washington School of Medicine, 325 9th Avenue Box 359608, Seattle, WA, 98104, USA.
Purpose: We describe a rare case of two simultaneous primary conjunctival melanomas in the same eye that were treated sequentially with both plaque brachytherapy and proton beam radiotherapy following wide surgical excision.
Observations: A 66-year-old male presented with two pigmented lesions that were concerning for conjunctival melanoma. One of the lesions was on the bulbar conjunctiva near the corneal limbus, and the other in the lower fornix.
Errors and Delays in Diagnosing Keratitis Fugax Hereditaria.
Am J Ophthalmol
March 2025
Eye Genetics Group, Folkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland; Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Purpose: To study errors and delays in diagnosing keratitis fugax hereditaria (KFH), an autosomal-dominant periodic corneal autoinflammatory disease caused by the NLRP3 variant c.61G>C, by reviewing the medical records of genetically confirmed Finnish patients with KFH and by determining the frequency of the c.61G>C variant in selected biobank samples.
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