Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/path.1711100109 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genotype characterization of tetrahydrobiopterin deficiency in two Tibetan children.
Heliyon
March 2024
Department of Medical Genetics and Prenatal Diagnosis, Sichuan Provincial Maternity and Child Health Care Hospital, Chengdu, Sichuan, 610031, China.
Background: Tetrahydrobiopterin (BH4) deficiency is a rare cause of hyperphenylalaninemia (HPA). The incidence of this condition varies based on region and ethnicity. In the early stages, patients typically do not exhibit any symptoms, and HPA is identified only through newborn screening for diseases.
View Article and Find Full Text PDFSynapsin 1 Ameliorates Cognitive Impairment and Neuroinflammation in Rats with Alzheimer's Disease: An Experimental and Bioinformatics Study.
Curr Alzheimer Res
January 2024
Department of Neurology, General Hospital of Ningxia Medical University. Yinchuan750004, China.
Background: Alzheimer's disease (AD) is a persistent neuropathological injury that manifests via neuronal/synaptic death, age spot development, tau hyperphosphorylation, neuroinflammation, and apoptosis. Synapsin 1 (SYN1), a neuronal phosphoprotein, is believed to be responsible for the pathology of AD.
Objective: This study aimed to elucidate the exact role of SYN1 in ameliorating AD and its potential regulatory mechanisms.
Metabolic alterations in urine among the patients with severe fever with thrombocytopenia syndrome.
Virol J
January 2024
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Article Synopsis
- - A study was conducted to understand the metabolic changes in urine of patients with severe fever with thrombocytopenia syndrome (SFTS) by comparing affected individuals to a healthy control group, ruling out other medical conditions.
- - The results highlighted that alterations in tryptophan and phenylalanine metabolism could differentiate between SFTS patients and healthy controls, with specific metabolites linked to the severity of the disease.
- - These findings suggest that targeting metabolic pathways related to tryptophan and phenylalanine could help in understanding SFTS better and developing potential treatments.
The differential sensitivity of the hypothalamic-hypophysial-ovarian axis to 5-hydroxytryptophan alters the secretion of estradiol.
Exp Physiol
March 2024
Laboratorio de Pubertad, Unidad de Investigación en Biología de la Reproducción, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Serotonin [5-hydroxytryptamine (5-HT)] modulates ovarian function. The precursor of 5-HT, 5-hydroxytryptophan (5-HTP), has been used to treat depression. However, the effects of 5-HTP on ovarian and reproductive physiology remain unknown.
View Article and Find Full Text PDFUntargeted metabolomics analysis in drug-naïve patients with severe obsessive-compulsive disorder.
Front Neurosci
June 2023
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction: Obsessive-compulsive disorder (OCD), characterized by the presence of obsessions and/or compulsions, is often difficult to diagnose and treat in routine clinical practice. The candidate circulating biomarkers and primary metabolic pathway alteration of plasma in OCD remain poorly understood.
Methods: We recruited 32 drug-naïve patients with severe OCD and 32 compared healthy controls and applied the untargeted metabolomics approach by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) to assess their circulating metabolic profiles.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!