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Positive susceptibility-based contrast imaging with dephased balanced steady-state free precession.
Magn Reson Med
March 2025
New Markets, Magnetic Resonance, Siemens Healthineers AG, Erlangen, Germany.
Purpose: Dephasing gradients can be introduced within a variety of gradient-echo pulse sequences to delineate local susceptibility changes ("White-Marker" phenomenon), e.g., for the visualization of metallic interventional devices which are otherwise difficult to display.
View Article and Find Full Text PDFDenoising complex-valued diffusion MR images using a two-step, nonlocal principal component analysis approach.
Magn Reson Med
March 2025
Center for Magnetic Resonance Research, Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Purpose: To propose a two-step, nonlocal principal component analysis (PCA) method and demonstrate its utility for denoising complex diffusion MR images with a few diffusion directions.
Methods: A two-step denoising pipeline was implemented to ensure accurate patch selection even with high noise levels and was coupled with data preprocessing for g-factor normalization and phase stabilization before data denoising with a nonlocal PCA algorithm. At the heart of our proposed pipeline was the use of a data-driven optimal shrinkage algorithm to manipulate the singular values in a way that would optimally estimate the noise-free signal.
Evaluation of Department of Defense hospital antimicrobial stewardship programs (ASPs) using a novel Core Elements scoring approach and modeling Core Elements scores with metrics related to ASP outcomes.
Infect Control Hosp Epidemiol
March 2025
Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Objective: Evaluate Department of Defense (DoD) antimicrobial stewardship programs (ASPs) by assessing the relationship between key clinical outcome metrics (antibiotic use, incidence of resistant pathogens, and incidence of infections) and CDC Core Element (CE) adherence.
Design: Retrospective, cross-sectional study of DoD hospitals in 2018 and 2021.
Methods: National Healthcare Safety Network Standardized Antimicrobial Administration Ratios (SAARs) were used to measure antibiotic use and microbiology results to evaluate four types of pathogen incidence.
Identification and validation of transcriptome-wide association study-derived genes as potential druggable targets for osteoarthritis.
Bone Joint Res
March 2025
Department of Orthopedics, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, China.
Aims: Osteoarthritis (OA) is a widespread chronic degenerative joint disease with an increasing global impact. The pathogenesis of OA involves complex interactions between genetic and environmental factors. Despite this, the specific genetic mechanisms underlying OA remain only partially understood, hindering the development of targeted therapeutic strategies.
View Article and Find Full Text PDFStone density can predict the number of ESWL treatments needed in patients with pancreatic duct calculi.
Scand J Gastroenterol
March 2025
Department of Abdominal surgery, Helsinki University Hospital, Helsinki, Finland.
Objectives: Extracorporeal shock wave lithotripsy (ESWL) with endotherapy (ET) is the first-line treatment in patients with chronic pancreatitis (CP) and main pancreatic duct stone (PDS). Our study aimed to evaluate factors that predict the outcome of ESWL in CP patients with PDS.
Methods: We retrospectively analyzed data of 166 patients with CP and radiopaque PDS.
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