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Doc Ophthalmol
March 2025
Department of Ophthalmology, Vanderbilt Clinic, Columbia University Irving Medical Center, 622 W 168th St 3rd Floor, New York, NY, 10032, USA.
Purpose: To describe a case of SLC37A3-associated retinitis pigmentosa (RP) and associated imaging and electroretinography findings.
Methods: The patient was evaluated at Columbia University Irving Medical Center using a comprehensive multimodal imaging protocol that included color fundus photography, fundus autofluorescence (FAF), and spectral-domain optical coherence tomography. Functional assessments were conducted using full-field electroretinography (ERG), following the ISCEV standard protocols to ensure consistent and reproducible measurements of photoreceptor activity.
Doc Ophthalmol
March 2025
Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
Purpose: To assess the repeatability of the multifocal electroretinogram (mfERG) in the 13-lined ground squirrel (13-LGS).
Methods: 13-LGS (Ictidomys tridecemlineatus, 2 M/4F, n = 12 eyes) were equally divided between 61-segment or 103-segment protocols containing two consecutive mfERG scans per session, and two total sessions performed one week apart per eye. The trough-to-peak amplitudes were analyzed under three conditions: raw, normalized to the optic nerve head (ONH), and normalized to the visual streak (VS).
J Zoo Wildl Med
March 2025
International Animal Rescue, Lime House, Regency Close, Uckfield, East Sussex, TN22 1DS, U.K.
The aim of this study was to descriptively characterize the ophthalmic findings identified in 43 adult sloth bears rescued from the dancing bear trade in India and examined at two sloth bear rehabilitation centers in Agra and Bannerghatta nr. Bangalore. Animals were selected where ocular disease was suspected except for two bears which were examined while anesthetized for other reasons (fight wound, health check).
View Article and Find Full Text PDFIntroduction: To evaluate the structure-function relationship between steady-state pattern electroretinogram (ssPERG), optical coherence tomography (OCT), and visual field (VF) tests, and to investigate indicators that enhance the detection of preperimetric and early-stage primary open angle glaucoma (POAG).
Methods: In this retrospective cohort study, patients with POAG and normal subjects who underwent ssPERG, OCT, and VF tests were included. We defined the ratio of the amplitudes from 0.
FASEB J
March 2025
Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota, USA.
The distribution of stored dietary vitamin A/all-trans-retinol (ROL) from the liver throughout the body is critical for maintaining retinoid function in peripheral tissues and for generating visual pigments for photoreceptor cell function. ROL circulates in the blood bound to the retinol binding protein 4 (RBP4) as RBP4-ROL. Two membrane receptors, RBPR2 in the liver and other non-ocular tissues, and STRA6 in the eye are proposed to bind circulatory RBP4 and this mechanism facilitates the internalization of ROL.
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