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Fatal Waterhouse-Friderichsen Syndrome caused by Streptococcus pneumoniae in a vaccinated adult with traumatic splenectomy: A case report.
Leg Med (Tokyo)
January 2025
University of Modena and Reggio Emilia, Italy. Electronic address:
Waterhouse-Friderichsen Syndrome (WFS) is a rare but life-threatening condition characterized by massive adrenal hemorrhage. WFS represents one of the features of the Overwhelming Post-Splenectomy Infection, which occurs any time after spleen removal and is recognized as the most serious complication in asplenic patients. We report a fatal case of WFS resulting from Streptococcus pneumoniae infection in a vaccinated and splenectomized patient.
View Article and Find Full Text PDFLong-term complications, survival and mortality in splenectomised adult transfusion-dependent thalassemia patients.
Transfus Apher Sci
January 2025
Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Background: Splenectomy is frequently performed in transfusion-dependent thalassemia (TDT) patients to lower blood transfusion needs but is associated with significant long-term complications, including sepsis, thrombosis, and pulmonary hypertension. This study examines the long-term complications, survival rates, and causes of mortality among adult patients with TDT who have undergone splenectomy in a low and middle-income country (LMIC).
Methods: A retrospective analysis was conducted on 103 adult TDT patients (≥18 years) who underwent splenectomy between July 2013 and March 2024.
The clinical range and management of spontaneous rupture of the pathological malarial spleen (SRPMS): A short case series from Sudan.
Int J Surg Case Rep
January 2025
Faculty of Medicine and Health Sciences, Omdurman Islamic University, Sudan.
Introduction: Spontaneous rupture of the pathological malarial spleen (SRPMS) is a rare condition with a mortality rate among travelers of approximately 38 %, whereas it was around 10 % for local citizens. The mortality rate for overwhelming post-splenectomy sepsis was reported to be about 50 %.
Methods: A retrospective study was conducted from febraury2022 to July 2022.
Prevention of Infections Among Pediatric Solid Organ Transplant Recipients With Asplenia or Hyposplenism.
Pediatr Transplant
February 2025
Department of Pediatrics, Division of Infectious Diseases, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Pediatric solid organ transplant (SOT) recipients with splenic dysfunction are at increased risk for infections, and tailored guidance on the management of asplenia/hyposplenism among SOT recipients is often lacking. The purpose of this article is to provide practice recommendations via a frequently asked questions (FAQs) format that focuses on three main domains: the identification of asplenia/hyposplenism among SOT recipients/candidates, prophylactic strategies for mitigating the risk of invasive disease associated with splenic dysfunction in the context of transplantation, and the provision of appropriate patient counseling on the risks associated with asplenia/hyposplenism. Answers to the FAQs are based on international expert opinion informed by practices for managing splenic dysfunction and associated data in other populations with asplenia.
View Article and Find Full Text PDFASO Author Reflections: Advancing Post-operative Infection Risk Assessment of CRS/HIPEC with Splenectomy.
Ann Surg Oncol
December 2024
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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