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Aflatoxin B-induced DNA adduct formation in murine kidney and liver.
Environ Toxicol Pharmacol
January 2025
Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239; Department of Molecular and Medical Genetics, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239.
Aflatoxicosis is a life-threatening nephrotoxic condition arising from eating foods highly contaminated with aflatoxin-producing molds. Additionally, chronic aflatoxin exposures are linked to enhanced hepatocellular carcinomas. Using recent advances in mass spectrometry for the detection of aflatoxin B (AFB) DNA adducts, we present data which show generation of these adducts in the kidney, albeit at ≈100-fold lower levels than in the liver of the same animal.
View Article and Find Full Text PDFComprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer.
Sci Rep
January 2025
Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh, 11451, Saudi Arabia.
Prostate cancer presents a major health issue, with its progression influenced by intricate molecular factors. Notably, the interplay between miRNAs and changes in transcriptomic patterns is not fully understood. Our study seeks to bridge this knowledge gap, employing computational techniques to explore how miRNAs and transcriptomic alterations jointly regulate the development of prostate cancer.
View Article and Find Full Text PDFHigh-Security Data Encryption Enabled by DNA Multi-Strand Solid-Phase Hybridization and Displacement in Inkjet-Printed Microarrays.
ACS Appl Mater Interfaces
January 2025
Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Multicolor fluorescent encryption systems that respond to specific stimuli have drawn widespread attention to data storage and encryption due to their low cost and facile data access. However, existing encryption systems are limited by encryption materials, restricting their encryption depth. This study uses DNA molecules as encryption materials that offer exceptional specificity and encryption depth within sequences.
View Article and Find Full Text PDFSmall-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA.
DNA Repair (Amst)
January 2025
Department of Chemistry and Stanford University, Stanford, CA 94305, United States. Electronic address:
A potentially promising approach to targeted cancer prevention in genetically at-risk populations is the pharmacological upregulation of DNA repair pathways. SMUG1 is a base excision repair enzyme that ameliorates adverse genotoxic and mutagenic effects of hydrolytic and oxidative damage to pyrimidines. Here we describe the discovery and initial cellular activity of a small-molecule activator of SMUG1.
View Article and Find Full Text PDFCorrecting a pathogenic mitochondrial DNA mutation by base editing in mice.
Sci Transl Med
January 2025
Graduate Program in Human Genetics, University of Miami Miller School of Medicine, 1501 NW 10th Avenue (M-860), Miami, FL 33136, USA.
Primary mitochondrial disorders are most often caused by deleterious mutations in the mitochondrial DNA (mtDNA). Here, we used a mitochondrial DddA-derived cytosine base editor (DdCBE) to introduce a compensatory edit in a mouse model that carries the pathological mutation in the mitochondrial transfer RNA (tRNA) alanine (mt-tRNA) gene. Because the original m.
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