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Intramuscular heroin-induced severe rhabdomyolysis and acute kidney injury-a case report.

Oxf Med Case Reports

November 2024

Clinic of Nephrology, UMHAT "Sveti Georgi", Plovdiv, 15 Vasil Aprilov Blvd., 4002, Bulgaria.

Rhabdomyolysis (RM) is characterised by the breakdown of skeletal muscle tissue, releasing toxic intracellular components into circulation. It presents with dark urine, muscle weakness, myalgia, and elevated creatine phosphokinase levels (CPK). Drug-induced RM is aetiologically significant.

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Poisoning-Induced Acute Kidney Injury: A Review.

Medicina (Kaunas)

August 2024

Department of Emergency Medicine, MacKay Memorial Hospital, Taipei 10449, Taiwan.

Article Synopsis
  • Acute kidney injury (AKI) is a serious condition often seen in hospitals, linked to various causes, including poisoning.
  • This review covers important aspects of poisoning-related AKI such as its definition, symptoms, mechanisms, and the lab tests used for diagnosis.
  • It also explores treatment options for AKI caused by specific toxins and substances, along with strategies for management, prevention, and understanding potential outcomes.
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Isolated renal mucormycosis (IRM) is a rare disease with high mortality, more commonly seen in immunocompromised patients. Management has traditionally included antifungal drugs with or without nephrectomy. We present the case of a 34-year-old female with a past medical history of type 1 diabetes mellitus and intravenous heroin use who presented with fever, flank pain, hematuria, and vomiting.

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Intravenous drug use (IVDU) is a major public health issue, associated with high mortality rates. The risk of overdose, cardiovascular and infectious complications are well known, but IVDU can also lead to different types of kidney disease. Patients can develop acute or chronic kidney injury due to direct nephrotoxicity of the drugs, or present with different types of glomerulonephritis, interstitial nephritis, and bacterial or viral infection-related nephropathy.

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Drug abuse has become a major problem of the modern world where drug-induced kidney injury can be caused by both prescribed drugs for clinical conditions and illegal (illicit) drugs or drugs of abuse. Heroin, cocaine, nicotine and alcohol are the most commonly abused drugs but with the emergence of various synthetic drugs, numerous novel descriptions of their nephrotoxic effects have been described. This review summarizes the key renal manifestations of recreational drugs as reported in case reports and case.

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