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Fibroin-Hybrid Systems: Current Advances in Biomedical Applications.
Molecules
January 2025
Laboratório de Bioengenharia, Universidade Federal de Itajubá, Itabira 35903-087, Minas Gerais, Brazil.
Fibroin, a protein extracted from silk, offers advantageous properties such as non-immunogenicity, biocompatibility, and ease of surface modification, which have been widely utilized for a variety of biomedical applications. However, in vivo studies have revealed critical challenges, including rapid enzymatic degradation and limited stability. To widen the scope of this natural biomacromolecule, the grafting of polymers onto the protein surface has been advanced as a platform to enhance protein stability and develop smart conjugates.
View Article and Find Full Text PDFRestoration of Genetic Code in Macular Mouse Fibroblasts via APOBEC1-Mediated RNA Editing.
Biomolecules
January 2025
Bioscience, Biotechnology and Biomedical Engineering Research Area, Japan Advanced Institute of Science and Technology, Nomi 923-1211, Japan.
RNA editing is a significant mechanism underlying genetic variation and protein molecule alteration; C-to-U RNA editing, specifically, is important in the regulation of mammalian genetic diversity. The ability to define and limit accesses of enzymatic machinery to avoid the modification of unintended targets is key to the success of RNA editing. Identification of the core component of the apoB RNA editing holoenzyme, APOBEC, and investigation into new candidate genes encoding other elements of the complex could reveal further details regarding APOBEC-mediated mRNA editing.
View Article and Find Full Text PDFThe Evolution of Antimicrobial Resistance in and New Strategies to Fight It.
Antibiotics (Basel)
January 2025
Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy.
is considered one of the prioritized ESKAPE microorganisms for the research and development of novel treatments by the World Health Organization, especially because of its remarkable persistence and drug resistance. In this review, we describe how this can be acquired by the enzymatic degradation of antibiotics, target site modification, altered membrane permeability, multidrug efflux pumps, and their ability to form biofilms. Also, the evolution of drug resistance in , which is mainly driven by mobile genetic elements, is reported, with particular reference to plasmid-associated resistance, resistance islands, and insertion sequences.
View Article and Find Full Text PDF[Directed evolution improves the catalytic activity of laccase in papermaking].
Sheng Wu Gong Cheng Xue Bao
January 2025
State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei University, Wuhan 430062, Hubei, China.
As a biocatalyst, laccase has been widely studied and applied in the papermaking industry. However, the low catalytic efficiency and poor stability of natural laccase limit its application in the pulping process. To develop the laccase with high activity and strong tolerance, we carried out directed evolution for modification of the laccase derived from and screened out the mutants F282L/F306L and Q275P from the random mutant library by high-throughput screening.
View Article and Find Full Text PDFRole of PARP-1 structural and functional features in PARP-1 inhibitors development.
Bioorg Chem
January 2025
FSBI A A Smorodintsev Research Institute of Influenza, Saint Petersburg, Russian Federation. Electronic address:
Poly(ADP-ribose) polymerase-1 (PARP-1) is the key enzyme among other PARPs for post-translational modification of DNA repair proteins. It has four functional domains for DNA-binding, automodification and enzymatic activity. PARP-1 participates in poly-ADP-ribosylation of itself or other proteins during DNA damage response.
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