The effect of gross vesicoureteric reflux in combination with urinary tract infection on the area of the renal parenchyma was analysed in 8, non-selected, girls during 3 to 6 years. A progressive significant decrease of the relative size of the kidneys with vesicoureteric reflux occurred as compared with that of kidneys with normal ureters. The decrease was mainly due to scars in the upper and lower poles. A positive correlation was found between the reduction of parenchyma and the number of episodes of pyelonephritis.
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