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Squamous Cell Carcinoma Originating From Mature Cystic Teratoma of the Ovary Diagnosed 10 Years After Initial Tumor Detection: A Case Report.
Cureus
December 2024
Obstetrics and Gynecology, Marunouchi Hospital, Matsumoto, JPN.
Malignant transformation is a rare complication of ovarian mature cystic teratoma that occurs in 1-3% of cases. We herein report a case of squamous cell carcinoma originating from mature cystic teratoma of the ovary diagnosed 10 years after initial tumor detection. A 69-year-old woman presented to the Department of Internal Medicine with a seven-month history of abdominal fullness.
View Article and Find Full Text PDFAt the nucleus of cancer: how the nuclear envelope controls tumor progression.
MedComm (2020)
February 2025
Historically considered downstream effects of tumorigenesis-arising from changes in DNA content or chromatin organization-nuclear alterations have long been seen as mere prognostic markers within a genome-centric model of cancer. However, recent findings have placed the nuclear envelope (NE) at the forefront of tumor progression, highlighting its active role in mediating cellular responses to mechanical forces. Despite significant progress, the precise interplay between NE components and cancer progression remains under debate.
View Article and Find Full Text PDFDevelopment of metastasis and survival prediction model of luminal and non-luminal breast cancer with weakly supervised learning based on pathomics.
PeerJ
January 2025
Departments of Clinical Pathology, The Second Affiliated Hospital of Medical College of Zhejiang University, Hangzhou, Zhejiang, China.
Objective: Breast cancer stands as the most prevalent form of cancer among women globally. This heterogeneous disease exhibits varying clinical behaviors. The stratification of breast cancer patients into risk groups, determined by their metastasis and survival outcomes, is pivotal for tailoring personalized treatments and therapeutic interventions.
View Article and Find Full Text PDFNovel transcripts of EMT driving the malignant transformation of oral submucous fibrosis.
Sci Rep
January 2025
Department of Oral and Maxillofacial Pathology and Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, 576104, India.
Oral submucous fibrosis (OSF) is a chronic, progressive, and fibrotic condition of the oral mucosa that carries an elevated risk of malignant transformation. We aimed to identify and validate novel genes associated with the regulation of epithelial-to-mesenchymal transition (EMT) in OSF. Genes regulating EMT were identified through differential gene expression analysis, using a LogFC threshold of -1 and + 1 and a padj value < 0.
View Article and Find Full Text PDFAssociation between frailty index and mortality in depressed patients: results from NHANES 2005-2018.
Sci Rep
January 2025
Department of Gastroenterology, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian, China.
This study investigated the relationship between the frailty index and all-cause and cause-specific mortality in patients with depression. We recruited 2,669 participants with depression from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018 and quantified their frailty status using a 53-item frailty index. Cox proportional hazards models were used to estimate hazard ratios (HR) and their 95% confidence intervals (CI).
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