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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Background: Alzheimer's disease (AD) is a devastating neurodegenerative disease with virtually no therapeutic interventions to reverse its pathology. Emerging studies emphasize the role of glial cells, particularly microglia, in brain homeostasis and AD progression. Notably, the adhesion G protein-coupled receptor GPR56 (also known as ADGRG1) is one of the critical genes defining yolk sac-derived microglia.
View Article and Find Full Text PDFAssessing molecular changes underlying isopropylated phenyl phosphate (IPP)-induced larval sensorimotor response deficits in zebrafish.
Ecotoxicol Environ Saf
December 2024
Department of Biological Sciences, Clemson University, Clemson, SC, USA. Electronic address:
Article Synopsis
- Isopropylated phenyl phosphates (IPP) are organophosphate flame retardants used in various products, but their leaching raises toxicity concerns due to limited toxicological studies.
- Using zebrafish embryos, the study found significant biological disruptions, including morphological changes and alterations in dopamine levels, alongside behavioral deficits at low concentrations.
- Further analysis indicated IPP inhibits retinoic acid receptor activity and caused hypermethylation in embryos, with distinct impacts observed in the eyes, revealing changes in genes related to nervous system functions.
Longitudinal volumetric analysis of compartments in chicken eggs using ultra-high-field magnetic resonance imaging.
Front Vet Sci
December 2024
Department of Ophthalmology, Rostock University Medical Center, Rostock, Germany.
Introduction: The chicken egg, with its compartments, is a widely used and popular animal model in experimental studies. This study aimed to quantify the volumes of the yolk/yolk sac, amniotic fluid, and chicken embryo using non-invasive ultra-high-field magnetic resonance imaging (UHF-MRI).
Materials And Methods: In total, 64 chicken eggs were examined using a 7 T UHF-MRI scanner, acquiring T2-weighted anatomical images of the entire egg from developmental day 1 to 16 (D1-D16).
Risk factors for methotrexate treatment failure in tubal ectopic pregnancy: a retrospective cohort study.
BMC Pregnancy Childbirth
December 2024
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, People's Republic of China.
Background: Ectopic pregnancy (EP) accounts for approximately 2% of all pregnancies, with tubal ectopic pregnancies (TEPs) being the most common type. Methotrexate (MTX) is a noninvasive and effective medical management option for TEP, but failure rates range from 10 to 36%, posing challenges in clinical practice. Identifying risk factors for MTX treatment failure is crucial to improve patient outcomes and guide clinical decision-making.
View Article and Find Full Text PDFImpact of late-stage hypoxic stimulation and layer breeder age on embryonic development, hatching and chick quality.
Poult Sci
December 2024
Laboratory of Regional Center of Excellence for Poultry Science, University of Lomé, 01 BP 1515, Lomé, Togo.
The present study examined the effects of breeder age and oxygen (O₂) concentrations during the late chorioallantoic membrane (CAM) growth stage on embryo development, hatching dynamics, chick quality, bone mineralization and hatchability. A total of 1200 eggs from 33- and 50-week-old ISA layer breeders, weighing 53.85 g and 60.
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