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Impact of circulating lymphocyte kinetics following radiotherapy on patient survival: A model-based meta-analysis.
Comput Biol Med
January 2025
Université de Caen Normandie, CNRS, Normandie Université, ISTCT UMR6030, GIP CYCERON, F-14000, Caen, France. Electronic address:
Introduction: Radiation-induced lymphopenia (RIL) has been shown to adversely affect the prognosis of cancer patients undergoing radiotherapy (RT). This model-based meta-analysis investigated the prognostic significance of lymphocyte counts both early and late after RT and examined the dose‒response relationship between post-RT lymphocyte levels and patient survival.
Methods: A literature search of published articles on the effect of RIL on cancer prognosis was conducted using the PubMed and Cochrane databases.
Slowly quenched, high pressure glassy B2O3 at DFT accuracy.
J Chem Phys
January 2025
Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.
Modeling inorganic glasses requires an accurate representation of interatomic interactions, large system sizes to allow for intermediate-range structural order, and slow quenching rates to eliminate kinetically trapped structural motifs. Neither first principles-based nor force field-based molecular dynamics (MD) simulations satisfy these three criteria unequivocally. Herein, we report the development of a machine learning potential (MLP) for a classic glass, B2O3, which meets these goals well.
View Article and Find Full Text PDFFirst-in-human, multicenter, open-label, phase I study of ATOR-1017 (evunzekibart), a 4-1BB antibody, in patients with advanced solid malignancies.
J Immunother Cancer
January 2025
Department of Oncology, Uppsala University Hospital, Uppsala, Sweden
Background: ATOR-1017 (evunzekibart) is a human agonistic immunoglobulin G4 antibody targeting the costimulatory receptor 4-1BB (CD137). ATOR-1017 activates T cells and natural killer cells in the tumor environment, leading to immune-mediated tumor cell death.
Methods: In this first-in-human, multicenter, phase I study, ATOR-1017 was administered intravenously every 21 days as a monotherapy to patients with advanced, unresectable solid tumors having received multiple standard-of-care treatments.
Freshwater Salinization Mitigated NO Emissions in Submerged Plant-Covered Systems: Insights from Attached Biofilms.
Environ Sci Technol
January 2025
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
Submerged plants (SMPs) play a critical role in improving water quality and reducing NO greenhouse gas emissions. However, freshwater salinization represents a major environmental challenge in aquatic systems. To investigate the impact of salinization on NO emissions, this study conducted indoor mesocosm experiments simulating SMP and nonsubmerged plant (Non_SMP) areas in freshwater lakes.
View Article and Find Full Text PDFGermination under the dark as an efficient method to enrich barley hordatine aglycones and to prepare a hordatine-rich fraction.
Food Chem
January 2025
Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, NC Research Campus, 500 Laureate Way, Kannapolis, North Carolina 28081, United States. Electronic address:
Barley (Hordeum vulgare L.; Poaceae), the second most important grain after wheat, contains phenolamides, specifically hordatines and their agmatinated precursors. Hordatines are the unique compounds found in barley, consumption of which is associated with beneficial effects for human health.
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