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The extracts from Centaurea species abolished the cytotoxic effects of doxorubicin on breast cancer cell line - MCF-7 and bortezomib on prostate cancer cell line- PC3.
Food Chem Toxicol
January 2025
Independent Medical Biology Unit, Faculty of Pharmacy, Medical University of Lublin, 8b Jaczewski Street 20-093 Lublin, Poland. Electronic address:
The use of plant extracts by cancer patients during chemotherapy poses potential risks, as they may reduce the effectiveness of treatment or interact negatively with chemotherapeutic drugs. There is a lack of comprehensive studies evaluating the effects of various Centaurea spp. plant extracts on chemotherapy outcomes, highlighting the need for caution and medical supervision.
View Article and Find Full Text PDFA nonsense variant in KRT31 is associated with autosomal dominant monilethrix.
Br J Dermatol
November 2024
Institute of Human Genetics, University of Bonn, Medical Faculty and University Hospital Bonn, Bonn, Germany.
Article Synopsis
- Monilethrix is a rare genetic hair disorder characterized by fragile hair with a beaded structure and potential keratosis pilaris or nail issues, linked to mutations in specific genes (KRT81, KRT83, KRT86 for dominant forms; DSG4 for recessive).
- This study aimed to uncover new genetic mutations in families with unexplained cases of autosomal-dominant monilethrix and to explore how these variants disrupt cell function.
- Through exome sequencing, researchers identified a significant mutation (c.1081G>T) in the KRT31 gene that affects keratin production, resulting in altered protein structure and function, confirmed through various laboratory techniques.
Procedural and Intermediate-term Results of the Electroanatomical-guided Cardioneuroablation for the Treatment of Supra-Hisian Second- or Advanced-degree Atrioventricular Block: the PIRECNA multicentre registry.
Europace
July 2024
Division of Cardiology, Rush University Medical Center, 1717 West Congress Parkway, Chicago, IL 60612, USA.
Article Synopsis
- A study was conducted to evaluate the success and outcomes of electroanatomical-guided cardioneuroablation (EACNA) in treating patients with vagally induced atrioventricular blocks (VAVBs).
- The results showed a high acute procedural success rate of 96.2%, but 14% of patients experienced recurrence of AVB or new syncopal episodes during a follow-up period of approximately 300 days.
- The findings suggest that EACNA is a promising option for patients with VAVB, but further research is needed to explore its effects on daytime symptom burden.
Decolonising the psychology curriculum: a perspective.
Front Psychol
June 2023
Research and Innovation Department, Southern Health NHS Foundation Trust, Southampton, United Kingdom.
Decolonisation seeks to reverse the impact of colonisation on minoritised groups. Governments, healthcare institutions, criminal justice and education systems have procedures and protocols deep-rooted in colonisation and operate through a western lens. Decolonisation reaches beyond increasing inclusivity and aims to re-establish history through the experiences and perspective of those most affected.
View Article and Find Full Text PDFFeasibility of CMR Imaging during Biventricular Pacing: Comparison with Invasive Measurement as a Pathway towards a Novel Optimization Strategy.
J Clin Med
June 2023
Department of Cardiology, Amsterdam UMC, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands.
Objectives: This prospective pilot study assessed the feasibility of cardiovascular magnetic resonance (CMR) imaging during biventricular (BIV) pacing in patients with a CMR conditional cardiac resynchronization therapy defibrillator (CRT-D) and compared the results with invasive volume measurements.
Methods: Ten CRT-D patients underwent CMR imaging prior to device implantation (baseline) and six weeks after device implantation, including CRT-on and CRT-off modes. Left ventricular (LV) function, volumes, and strain measurements of LV dyssynchrony and dyscoordination were assessed.
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