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Genetic diversity atlas of Brucella melitensis strains from Sichuan Province, China.
BMC Microbiol
January 2025
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Human brucellosis is a re-emerging disease in Sichuan Province, China. In this study, bacteriology, conventional bio-typing, multi-locus sequence typing (MLST), and multiple locus variable-number tandem repeat analysis (MLVA) were applied to preliminarily characterize the strains in terms of genetic diversity and epidemiological links. A total of 101 Brucella strains were isolated from 16 cities (autonomous prefectures) from 2014 to 2021, and all of the strains were identified as Brucella melitensis bv.
View Article and Find Full Text PDFIn silico MLVA Analysis of Brucella melitensis from Human and Livestock in Iran.
Curr Microbiol
January 2025
Agricultural Research, Education and Extension Organization (AREEO), Razi Vaccine and Serum Research Institute (RVSRI), Karaj, Iran.
Brucellosis, a zoonotic disease caused by Brucella spp. globally, is of great significance not only to livestock but also to public health. The most significant of the twelve species is Brucella melitensis.
View Article and Find Full Text PDFDetection and Molecular Diversity of in Pastoral Livestock in North-Eastern Ethiopia.
Pathogens
December 2024
Institute of Biotechnology, Addis Ababa University, Addis Ababa P.O. Box 1176, Ethiopia.
Brucellosis is a neglected zoonotic disease affecting livestock and humans that remains endemic in Ethiopia. Despite its prevalence, only a few studies have identified species circulating in livestock in the country. This study aimed to determine the species responsible for infections in livestock in the Afar region of Ethiopia and characterize the isolates using whole-genome single nucleotide polymorphism (wgSNP) analysis and in silico multi-locus sequence typing (MLST).
View Article and Find Full Text PDFMultiple lineages are driving the human brucellosis epidemic in Shaanxi Province, China: evidence from whole genome sequencing-based analysis.
Front Cell Infect Microbiol
November 2024
Department of Plague and Brucellosis, Shaanxi Center for Disease Control and Prevention, Xi'an, China.
Article Synopsis
- Human brucellosis is a significant public health issue in Shaanxi Province, China, and understanding its transmission patterns is essential for creating effective control strategies.
- The study identified 189 strains of the pathogen using bio-typing and whole genome sequencing, revealing genetic diversity with two clades (A and B) and 19 sequence types (STs).
- The findings indicate that the outbreak is fueled by multiple indigenous lineages, highlighting the need for targeted control measures to address this zoonotic disease.
Origin tracking of Brucella strain B. melitensics bv.3 ARQ-070 using biochemical and genomic studies.
FEMS Microbiol Lett
January 2024
Inner Mongolia Center for Disease Control and Research, Hohhot 010051, China.
To conduct an origin tracking and genomic study of the Brucella strain B. melitensis bv.3 ARQ-070, with the aim of addressing the challenges posed by the highly conserved genome of Brucella to conventional typing methods and to gain an understanding of the geographic distribution and interspecies transmission of this pathogen in China.
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