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Expression of phosphatidylethanolamine N-methyltransferase in human hepatocellular carcinomas.
Oncology
September 2003
Department DISCAFF, University of East Piedmont 'Amedeo Avogadro', Novara, Italy.
Objective: Hepatic phosphatidylethanolamine is converted into phosphatidylcholine by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT) when the dietary choline supply is inadequate. Our previous reports implicated PEMT in the regulation of hepatocyte growth and transformation. In the present study, we analyzed PEMT activity, PEMPT gene status and its mRNA expression in 29 human hepatocellular carcinomas (HCC).
View Article and Find Full Text PDF[Organ culture of human tissue as study model of hormonal and pharmacological regulation of benign prostatic hyperplasia and of prostatic cancer].
Acta Urol Belg
March 1995
Service d'Urologie et Laboratoire d'Histologie, Université Libre de Bruxelles.
We have established organ cultures of human prostate in vitro analysis of the hormone responsiveness of prostatic carcinoma. The influence of dihydrotestosterone (DHT), the epidermal growth factor (EGF) and prolactin (PRL) was assessed on the proliferation rate of 30 benign human prostatic hyperplasias (BPH) maintained for 48 hours as short-term primary cultures. The influence exerted by the EGF, the DHT and the PRL on the BPH cell proliferation was characterized by adding these compounds alone or in combination to the culture media.
View Article and Find Full Text PDFHistoautoradiographical detection of DNA repair synthesis in different organs of mice after methylnitrosourea "in situ".
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove
August 1996
Department of Anatomy Medical Faculty of Charles University, Hradec, Králové
Methylnitrosourea (MNU) was applied by gavage into the stomach in a dose of 123.1 mg/kg. Hydroxyurea (250 mg/kg) and 6 (3)H thymidine (dTh - 2 MBq/g) were injected intraperitoneally.
View Article and Find Full Text PDFCell kinetics of anagen scalp hairs under physiological and pathological conditions.
Skin Pharmacol
July 1994
Department of Dermatology, University of Erlangen, FRG.
The cell kinetics of anagen scalp hair bulbs taken by punch biopsies from healthy male volunteers (n = 50) were determined at defined bulbar hair segments using microdissection and DNA flow cytometry. The highest proliferative activity (S phase) was measured within the lower most bulbar segment (14.0%) but decreased to the Auber's segment (7.
View Article and Find Full Text PDFThe experiment on 90 rabbits and 30 rats has been conducted to compare the effect of different regimes of hyperbaric oxygenation (HBO) (pressure of oxygen: 3 ata, 2 ata, oxygen-air mixture: 3 ata and 1 ata, respectively) on the morphofunctional state of intact and ischemic myocardium with experimental infarction. The histoautoradiographic method using 3H-thymidine and 3H-uridine, the precursors of nucleic acids' synthesis, proved a good criterion of viability and activity of the regenerative processes in cardiomyocytes of perinfarction and necrosis-distant zones of the heart. The best effect has been obtained when using HBO regime with oxygen pressure 2 ata, the highest damaging effect--oxygen (3 ata)-air (1 ata) mixture.
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