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The Dynamic Role of Curcumin in Mitigating Human Illnesses: Recent Advances in Therapeutic Applications.
Pharmaceuticals (Basel)
December 2024
Core Labs, King Abdullah University of Science and Technology (KAUST), Thuwal 23955, Saudi Arabia.
Herbal medicine, particularly in developing regions, remains highly popular due to its cost-effectiveness, accessibility, and minimal risk of adverse effects. L., commonly known as turmeric, exemplifies such herbal remedies with its extensive history of culinary and medicinal applications across Asia for thousands of years.
View Article and Find Full Text PDFInsights into Within-Host Evolution and Dynamics of Oral and Intestinal Streptococci Unveil Niche Adaptation.
Int J Mol Sci
December 2024
Division of Oral Microbiology and Immunology, Department of Operative Dentistry, Periodontology and Preventive Dentistry, Rheinisch-Westfälische Technische Hochschule (RWTH) University Hospital, 52074 Aachen, Germany.
The oral-gut axis is a complex system linking the oral cavity and gastrointestinal tract, impacting host health and microbial composition. This study investigates genetic changes and adaptive mechanisms employed by streptococci-one of the few genera capable of colonizing oral and intestinal niches-within the same individual. We conducted whole-genome sequencing (WGS) on 218 streptococcal isolates from saliva and fecal samples of 14 inflammatory bowel disease (IBD) patients and 12 healthy controls.
View Article and Find Full Text PDFAdvancements in dual biologic therapy for inflammatory bowel diseases: efficacy, safety, and future directions.
Therap Adv Gastroenterol
January 2025
Department of Digestive Tract Diseases, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
Inflammatory bowel diseases (IBDs), primarily encompassing ulcerative colitis and Crohn's disease, represent a challenging spectrum of disorders with a multifaceted pathogenesis. Despite the array of available treatments, a demand for novel therapeutic options persists to achieve remission in a broader patient population. Research findings indicate that relying solely on a single biologic drug may limit future treatment choices, prompting consideration for a more suitable shift from step-up to top-down strategies in certain cases.
View Article and Find Full Text PDFIntestinal Colonization of Multidrug-Resistant Organisms: Identification and Antibiotic Susceptibility Patterns of Bacteria Isolated From Healthy Human Fecal Specimens.
Cureus
December 2024
Clinical Microbiology, Prathima Institute of Medical Sciences, Karimnagar, IND.
Introduction Intestinal carriage of multidrug-resistant organisms (MDROs) in healthy populations could amplify resistant bacteria, which may increase the risk of infections by these bacteria in the community and in the hospital. This study investigated the prevalence of colonization of multidrug-resistant (MDR) bacteria in the intestines of healthy individuals in South India. Methods A prospective study was conducted for six months at a tertiary care teaching hospital.
View Article and Find Full Text PDFMeasurements on slope parameter mapping based on dual-energy CT enterography for improving Crohn's disease diagnosis and inflammatory activity evaluation.
Sci Rep
January 2025
Department of Radiology, Zhongshan Hospital Affiliated to Xiamen University, School of Medicine, Xiamen University, No.201-209 Hubinnan Road, Siming District, Xiamen, 361004, Fujian Province, China.
Article Synopsis
- The study evaluates the effectiveness of slope parameter images (SPI) from dual-phase dual-energy CT enterography (DE-CTE) for diagnosing and assessing Crohn's disease (CD) activity.
- Researchers analyzed data from 76 CD patients and 53 controls, finding significant differences in dual-phase SP and HU values between groups, indicating higher values in affected individuals.
- The findings suggest that the AP SP of mesenteric fat shows the highest diagnostic potential for CD, emphasizing the usefulness of SPI in both diagnosis and assessing inflammation levels.
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