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Odontogenic myxoma: A clinicopathological study over 15 years and immunohistochemical analysis.
Heliyon
October 2024
Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
Objective: and rationale: Odontogenic myxoma is an uncommon odontogenic tumor with locally aggressive behavior. The clinicopathological studies of odontogenic myxoma in Asian countries are very limited and only few studies have investigated the immunohistochemical profiles of the tumor. This study aims to investigate the clinicopathological and immunohistochemical features of odontogenic myxoma at the Faculty of Dentistry, Mahidol University over a 15-year period.
View Article and Find Full Text PDFInfantile Sinonasal Tract Myxomas with Orbital Involvement: Presentation of Two Cases and Comprehensive Literature Review.
J Clin Med
November 2024
Ophthalmology Department, The Children's Hospital at Westmead, Sydney, NSW 2145, Australia.
Our aim is to present two cases of infantile sinonasal tract myxoma with orbital involvement and conduct a comprehensive literature review of the topic. We aim to provide a summary of the presentation of infantile sinonasal tract myxomas to effectively aid clinicians in considering this rare entity as a potential diagnosis. We present a case series and a retrospective review of the published literature in the English language.
View Article and Find Full Text PDFOdontogenic Myxomas Harbor Recurrent Copy Number Alterations and a Distinct Methylation Signature.
Am J Surg Pathol
October 2024
Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands.
Article Synopsis
- Odontogenic myxoma is a rare and aggressive benign tumor found in jaw areas, with no known molecular mechanisms or diagnostic markers currently.
- The study examined DNA methylation and copy number variations in 16 odontogenic myxomas to uncover potential new diagnostic signatures using advanced genomic techniques.
- Findings revealed a unique DNA methylation profile and recurrent chromosomal gains in the tumors, suggesting these genetic characteristics could aid in diagnosis, but further research is necessary to understand their underlying genetic causes.
Sinonasal Myxoma in an Infant: Observations on Its Distinctiveness and a Discussion on Potential Reclassification As Infantile Intraosseous Myxoid Desmoid Fibromatosis.
Cureus
August 2024
Department of Plastic Surgery, Kobe University Graduate School of Medicine, Kobe, JPN.
Article Synopsis
- Sinonasal myxomas (SNMs) are a specific type of tumor found in the paranasal sinuses and maxillae of infants, as seen in a case involving a 15-month-old.
- After initial surgery, the patient's tumor recurred, but a second surgery using marginal excision was successful with no further recurrences.
- SNMs have unique clinical and histological traits, and their positive β-catenin staining, unlike odontogenic myxomas which are negative for it, suggests they could be classified as a separate disease, prompting potential changes in treatment approaches.
Conservative Management of Odontogenic Fibromyxoma of the Maxilla: A Case Report.
Cureus
May 2024
Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Odontogenic fibromyxoma typically presents as painless swelling in the jaw, and clinically, it grows slowly, becoming benign and asymptomatic. It causes the cortical plates to expand gradually, which leads to mobility and drifting of the teeth. Root resorption is also common.
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