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Early developmental trajectories of the impaired hand in infants with unilateral cerebral palsy.
Dev Med Child Neurol
January 2025
Queensland Cerebral Palsy and Rehabilitation Research Centre, Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Australia.
Aim: To identify developmental trajectories of impaired hand function in infants aged 3 to 15 months with unilateral cerebral palsy (CP).
Method: Sixty-three infants (37 male; median gestational age 37 weeks [interquartile range 30-39.1 weeks]) recruited as part of a randomized trial with a confirmed diagnosis of unilateral CP were included.
Intranasal administration of antiseizure drugs using new formulation trends: one step closer to reach clinical trials.
Expert Opin Drug Deliv
January 2025
CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
Introduction: Although there are numerous options for epilepsy treatment, its effective control continues unsatisfactory. Thus, search for alternative therapeutic options to improve the efficacy/safety binomial of drugs becomes very attractive to investigate. In this context, intranasal administration of antiseizure drugs formulated on state-of-the-art nanosystems can be a promising strategy.
View Article and Find Full Text PDFDrought tolerance as an evolutionary precursor to frost and winter tolerance in grasses.
Evolution
January 2025
Department of Ecology, Environment and Plant Sciences, Stockholm University, Stockholm, Sweden.
Accumulating evidence is suggesting more frequent tropical-to-temperate transitions than previously thought. This raises the possibility that biome transitions could be facilitated by precursor traits. A wealth of ecological, genetic and physiological evidence suggests overlap between drought and frost stress responses, but the origin of this overlap, i.
View Article and Find Full Text PDFDiversity patterns and knowledge gaps of Atlantic Forest epiphyllous bryophytes: a highly neglected group.
Ann Bot
January 2025
Laboratório de Ecologia e Biogeografia de Plantas, Departamento de Biodiversidade, Setor Palotina, Universidade Federal do Paraná, Rua Pioneiro, 2153, Jardim Dallas, CEP 85950 000, Palotina, Paraná, Brazil.
Background: Epiphyllous bryophytes are a group of plants with complex adaptations to colonize the leaves of vascular plants and are considered one of the most specialized and sensitive groups to environmental changes. Despite their specificity and ecological importance, these plants represent a largely neglected group in relation to scientific research and ecological data. This lack of information directly affects our understanding of biodiversity patterns and compromises the conservation of this group in threatened ecosystems.
View Article and Find Full Text PDFCircadian Misalignment Impacts Cardiac Autonomic Modulation in Adolescence.
Sleep
January 2025
Sleep Research & Treatment Center, Department of Psychiatry & Behavioral Health, Penn State University, College of Medicine, Hershey PA, USA.
Study Objectives: Although heart rate variability (HRV), a marker of cardiac autonomic modulation (CAM), is known to predict cardiovascular morbidity, the circadian timing of sleep (CTS) is also involved in autonomic modulation. We examined whether circadian misalignment is associated with blunted HRV in adolescents as a function of entrainment to school or on-breaks.
Methods: We evaluated 360 subjects from the Penn State Child Cohort (median 16y) who had at least 3-night at-home actigraphy (ACT), in-lab 9-h polysomnography (PSG) and 24-h Holter-monitoring heart rate variability (HRV) data.
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