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Preclinical Development of Magnetic Nanoparticles for Hyperthermia Treatment of Pancreatic Cancer.
ACS Appl Mater Interfaces
January 2025
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT), Vall d'Hebron Institute of Research (VHIR), 08035 Barcelona, Spain.
Pancreatic ductal adenocarcinoma (PDAC) is a very challenging disease with a very poor prognosis. It is characterized by a dense desmoplastic stroma that hampers drug penetration and limits the effectiveness of conventional chemotherapy (CT). As an alternative, the combination of CT with hyperthermia (HT) has been proposed as an innovative treatment modality for PDAC.
View Article and Find Full Text PDFMolecular dependencies and genomic consequences of a global DNA damage tolerance defect.
Genome Biol
December 2024
Division of Tumor Biology & Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Background: DNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. In mammalian cells, DDT is regulated by two independent pathways, controlled by the polymerase REV1 and ubiquitinated PCNA, respectively.
Results: To determine the molecular and genomic impact of a global DDT defect, we studied Pcna;Rev1 compound mutants in mouse cells.
Hydrogel-antimicrobial peptide association: A novel and promising strategy to combat resistant infections.
Colloids Surf B Biointerfaces
March 2025
Laboratory of Bio & Nano Materials, Drug Delivery and Controlled Release, Department of Microbiology, Faculty of Health Sciences, University of Talca, Talca 3460000, Chile. Electronic address:
Infections from multi-drug resistant bacteria (MDRB) have raised a worldwide concern, with projections indicating that fatalities from these infections could surpass those from cancer by 2050. This troubling trend is influenced by several factors, including the scarcity of new antibiotics to tackle challenging infections, the prohibitive costs of last-resort antibiotics, the inappropriate use of antimicrobial agents in agriculture and aquaculture, and the over-prescription of antibiotics in community settings. One promising alternative treatment is the application of antimicrobial peptides (AMPs) against MDRB.
View Article and Find Full Text PDFDDT and Its Metabolites in Ethiopian Aquatic Ecosystems: Environmental and Health Implications.
Environ Health Insights
December 2024
School of Environmental Health Science, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Background: Despite its significant application, DDT and its metabolites pose a potential threat to the environment. Therefore, data on environmental and health concerns must thus be investigated.
Objective: The objective of this study was to assess the environmental and human health risks posed by DDT and its metabolites in Ethiopian surface waters.
Biological concentrations of DDT metabolites and breast cancer risk: an updated systematic review and meta-analysis.
Rev Environ Health
December 2024
Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.
The question of whether dichlorodiphenyltrichloroethane (DDT) exposure is related to breast cancer (BC) remains unanswered, possibly due to methodological constraints in the studies that have been performed. We aimed to update and synthesize the available epidemiological evidence on the relationship of p,p'-DDT, o,p'-DDT and p,p'-dichlorodiphenyldichloroethylene (p,p'- DDE) biological concentrations with female BC, focusing in methodological characteristics not addressed in previous reviews. We conducted an overview of reviews and a systematic review and meta-analysis.
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