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Rationale: Airflow obstruction refractory to β2 adrenergic receptor (β2AR) agonists is an important clinical feature of infant respiratory syncytial virus (RSV) bronchiolitis, with limited treatment options. This resistance is often linked to poor drug delivery and potential viral infection of airway smooth muscle cells (ASMCs). Whether RSV inflammation causes β2AR desensitization in infant ASMCs is unknown.
View Article and Find Full Text PDFDoes TikTok contribute to eating disorders? A comparison of the TikTok algorithms belonging to individuals with eating disorders versus healthy controls.
Body Image
December 2024
Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia; Unforgettable.Me, Melbourne, Australia.
TikTok employs sophisticated algorithms to deliver users increasingly personalised content over time. We investigated the potential for these algorithms to exacerbate eating disorder symptoms by analysing 1.03 million TikTok videos delivered to 42 individuals with eating disorders (76 % anorexia nervosa) and 49 healthy controls over one month.
View Article and Find Full Text PDFEvaluation of Injectate Distribution of the Middle Mental Nerve Block Within the Mandibular Canal in a Cadaveric Canine Model.
J Vet Dent
January 2025
Dental Care for Pets, Melbourne, Australia.
Awareness among veterinarians has increased regarding the need for comprehensive pain relief, but many companion animal veterinarians do not administer regional analgesia pre-emptively during dental procedures. The middle mental nerve (MMN) block desensitizes the ipsilateral mandibular incisor and canine teeth as well as soft tissues rostral to the delivery site. There is little published information on the efficacy of the MMN block in dogs.
View Article and Find Full Text PDFHLA-DR regulatory T cells and IL-10 are associated with success or failure of desensitization outcomes.
Allergy
September 2024
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Background: Omalizumab (XOLAIR®)-assisted multi-food oral immunotherapy (mOIT) has been shown to safely, effectively, and rapidly desensitize patients with multiple food allergies. In our clinical trial (NCT02626611) on omalizumab-assisted mOIT, different desensitization outcomes (success or failure of desensitization) were observed following a period of either continued or discontinued mOIT. However, the association between the immunological changes induced by omalizumab-assisted mOIT and desensitization outcomes has not yet been fully elucidated.
View Article and Find Full Text PDFBeyond the Iron Throne: exploring the representation of homosexuality in the series .
Front Sociol
July 2024
Department of English, School of Social Sciences and Languages, Vellore Institute of Technology, Chennai, India.
Introduction: This research delves into the representation of homosexuality in the television series , adapted from George R.R. Martin's saga.
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