Similar Publications
The role of cellular lipid metabolism and lipid-lowering drugs in periodontitis.
Int Immunopharmacol
March 2025
Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran. Electronic address:
Initiated by bacteria, periodontitis (PD) is a complex, chronic inflammatory disease of the supporting tissue of the gums and teeth. Also linked to PD include human papillomavirus (HPV), hepatitis B virus (HBV), Epstein-Barr virus (EBV), human cytomegalovirus (CMV), and Herpes Simplex Virus (HSV). PD also raises the risk of cardiovascular disease (CVD) because it triggers inflammatory reactions throughout the body.
View Article and Find Full Text PDFBackground And Aims: The ongoing COVID-19 pandemic necessitates a deeper understanding of risk factors associated with severe outcomes. Chronic Periodontitis, a persistent inflammatory condition affecting the gums, may be linked to increased COVID-19 severity. This study aimed to determine the relationship between periodontitis and the severity of lung infection caused by COVID-19.
View Article and Find Full Text PDFPlant and animal-derived fusion nanovesicles rescue inflammation-compromised osteogenic potential of periodontal ligament stem cells.
Front Cell Dev Biol
February 2025
Endoscopy Center and Gastroenterology Department, Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Diseases, Shenzhen Children's Hospital, Shenzhen, China.
Periodontitis is a chronic inflammatory disease affecting the supporting tissues of the teeth and has emerged as a global public health issue. Current therapies primarily address pathogenic factors and alleviate symptoms, with limited options available for complete restoration and reconstruction of already absorbed periodontal bone tissue. In this study, we developed a nanotherapeutic strategy utilizing fusion nanovesicles (FVs) to modulate the inflammatory microenvironment and create a regenerative niche for periodontal ligament stem cells (PDLSCs), which play a crucial role in periodontal tissue repair.
View Article and Find Full Text PDFMetabolomic Profiles of Oral Rinse Samples to Distinguish Severe Periodontitis Patients From Non-Periodontitis Controls.
J Periodontal Res
March 2025
Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Aims: To explore the potential of metabolomic profiles of oral rinse samples to distinguish between patients with severe periodontitis (stage III/IV) and non-periodontitis controls. This is coupled to an analysis of differences in metabolomic profiles between individuals without periodontitis, patients with localized periodontitis, and patients with generalized periodontitis.
Methods: Periodontitis patients and controls were recruited, all aged ≥ 40 years.
Association between periodontal disease and age-related cognitive impairment: a narrative review.
BMC Oral Health
March 2025
Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, 7-430, Morioka, Obu, 474-8511, Aichi, Japan.
Background: Previous studies have shown associations between periodontal disease and age-related cognitive impairment. However, little is known about the different cognitive functions that may be affected in patients with periodontal disease.
Methods: We reviewed the recent literature to better understand the bidirectional relationship between cognitive function and periodontal disease, and to explore the cognitive assessments that may be useful when investigating this relationship.
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