Oxolinic acid was successfully used in eradicating bacteriuria in 86% of a highly selected group of 42 patients with chronic and recurrent urinary infections. Thirty-eight (92%) of patients had underlying renal abnormalities, 19 (45%) had impaired renal function. Emergence of resistant organisms in 3 patients (7%), and a high incidence of side effects necessitating withdrawal of treatment in 12 patients (29%), limit the usefulness of this agent to special situations. In patients with moderate and severe renal impairment, oxolinic acid achieves adequate urinary concentration, does not accumulate in the serum and is not nephrotoxic. The drug is safe and effective to use in patients with renal impairment.
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