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The burden of irritable bowel syndrome and functional dyspepsia in Poland: a cross-sectional study from West Pomeranian Voivodship.
BMC Gastroenterol
January 2025
Department of Gastroenterology, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, Szczecin, 71-254, Poland.
Background: Functional gastrointestinal disorders (FGIDs), now known as disorders of gut-brain interaction (DGBIs), such as Irritable Bowel Syndrome (IBS) and Functional Dyspepsia (FD), significantly impact global health, reducing quality of life and burdening healthcare systems. This study addresses the epidemiological gap in Poland, focusing on the West Pomeranian Voivodeship.
Methods: We conducted a cross-sectional study of 2070 Caucasian patients (58.
Pulmonary artery denervation by noninvasive stereotactic radiotherapy: a pilot study in swine models of pulmonary hypertension.
Nat Commun
January 2025
Department of Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Catheter-based pulmonary artery denervation (PADN) has achieved promising outcomes to treat pulmonary hypertension (PH). We herein present stereotactic body radiotherapy (SBRT) as a novel noninvasive approach for PADN. A single fraction of 15 Gy, 20 Gy or 25 Gy was delivered for PADN in a thromboxane A2 (TxA2) - induced acute PH swine model.
View Article and Find Full Text PDFDeterminants of Caregiver Burden Among Spouses of Patients With Kidney Failure: A Qualitative Study.
Am J Kidney Dis
January 2025
Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, the Netherlands.
Rationale & Objective: Spousal caregivers participate extensively in the care of patients with kidney failure. Although previous studies suggested that these caregivers experience a high burden, a comprehensive understanding of the determinants of this burden and strategies to alleviate it are needed. Therefore, this study sought to explore the contributing and alleviating determinants of burden in spousal caregivers of patients with kidney failure.
View Article and Find Full Text PDFSustained release of Ambrisentan Solid Lipid Nanoparticles for the treatment of Hypertension: Melt Emulsification Method.
Ann Pharm Fr
January 2025
SVKM's NMIMS School of Pharmacy and Technology Management Shirpur, Dhule, India-425405, India; SVKM Institute of Pharmacy, Dhule, Maharashtra-424001, India. Electronic address:
Objective: The beneficial usefulness is limited because of its deprived solubility and bioavailability. The recent work deals with the advancement of solid lipid nanoparticles of Ambrisentan for the effective therapy of pulmonary hypertension intended for oral delivery.
Material And Methods: The solid lipid nanoparticles of Ambrisentan were developed using the melt-emulsification method.
Construction of predictive model for the risk of acute lactic acidosis in patients with ischemic stroke during the ICU stay: A study based on the medical information Mart for intensive care database.
J Clin Neurosci
January 2025
Department of Neurology, Beijing Shunyi Hospital, Beijing 101300, PR China. Electronic address:
Background: This study aims to identify the factors influencing the risk of lactic acidosis (LA) in patients with ischemic stroke (IS) and to develop a predictive model for assessing the risk of LA in IS patients during their stay in the intensive care unit (ICU).
Methods: A retrospective cohort design was employed, with data collected from the Medical Information Mart for Intensive Care (MIMIC)-III and MIMIC-IV databases spanning from 2001 to 2019. LA was defined as pH < 7.
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